Evidence map›Paper›PMID 27091893›Full record

ReviewHypertension (Dallas, Tex. : 1979)2016

Refractory Hypertension: A Novel Phenotype of Antihypertensive Treatment Failure.

Tanja Dudenbostel, Mohammed Siddiqui, Suzanne Oparil, David A Calhoun

Registry-linked trialAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06450327 (Resistant Hypertension An Open, Complicated), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06450327 recruitingnot on this mapstarted 2024, after this paper: background citation

Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus")

TypeobservationalSponsorUniversity of Campinas, BrazilRan2024 to 2026Enrolled80ConditionsHypertension, Resistant HypertensionArmsThis is a cross-sectional observational study
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Frontiers in genetics · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  14. 2022 Renal denervation therapy for the treatment of hypertension: a statement from the Thai Hypertension Society.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
  15. Article
  16. Review
  17. Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tanja DudenbostelFrom the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham. tduden@uab.edu.
Mohammed SiddiquiFrom the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham.
Suzanne OparilFrom the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham.
David A CalhounFrom the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham.

Funding

Mechanisms of Refractory HypertensionR01HL113004 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OPARIL, SUZANNE · 2014 to 2018
$2.5M
Etiology of Sleep APnea-Related HyperaldosteronismR01HL075614 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CALHOUN, DAVID A · 2004 to 2011
$2.4M
NHLBI NIH HHS R01 HL075614NHLBI NIH HHS R01 HL113004
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug ResistanceHypertensionAntihypertensive AgentsBlood PressureHumansPrevalencePrognosisRisk FactorsSympathetic Nervous SystemTerminology as TopicAntihypertensive Agents

Identifiers

PMID27091893
PMCPMC5425297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.