Evidence map›Paper›PMID 27091859›Full record

ArticleThe Journal of international medical research2016

Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour.

Fumiaki Matsubara, Takuyuki Katabami, Shiko Asai, Yasushi Ariizumi, Ichiro Maeda, Masayuki Takagi, May McNamara Keely, Katsuhiko Ono, Takashi Maekawa, Yasuhiro Nakamura and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fumiaki MatsubaraDepartment of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Takuyuki KatabamiDepartment of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan t2kataba@marianna-u.ac.jp.
Shiko AsaiDepartment of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan.
Yasushi AriizumiDepartment of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Ichiro MaedaDepartment of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Masayuki TakagiDepartment of Pathology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
May McNamara KeelyDepartment of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Katsuhiko OnoDepartment of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Takashi MaekawaDepartment of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Yasuhiro NakamuraDepartment of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Yasushi TanakaDepartment of Internal Medicine, Division of Metabolism and Endocrinology, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Hironobu SasanoDepartment of Anatomical Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
St. Marianna University School of Medicine · JPTohoku University · JPYokohama City Seibu Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma.

methodThis study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated the association between the extent of the IGF-1 and IGF-1R immunoreactivity and several clinicopathological characteristics (age, sex and maximum tumour dimension).

resultsThe study examined a total of 29 sporadic schwannoma specimens. IGF-1 and IGF-1R immunoreactivity was detected in the majority of the specimens regardless of their anatomical location. IGF-1 and IGF-1R were not co-localized. There was no association between the extent of the IGF-1 and IGF-1R immunoreactivity and the clinicopathological characteristics of the patients.

conclusionsAs IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine-paracrine mechanism.

Indexed as

DemographyFemaleHumansImmunohistochemistryInsulin-Like Growth Factor IMaleMiddle AgedNerve Sheath NeoplasmsNeurilemmomaReceptor, IGF Type 1Retroperitoneal NeoplasmsInsulin-Like Growth Factor IReceptor, IGF Type 1autocrine–paracrine loopimmunostaininginsulin-like growth factor 1insulin-like growth factor 1 receptorperipheral nerve sheath tumourSchwannoma

Identifiers

PMID27091859
PMCPMC5536698
OpenAlexW2340426763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.