ArticleThe British journal of ophthalmology2017
Relationship between macular pigment and visual function in subjects with early age-related macular degeneration.
Article in The British journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Comparing 2-dimensional macular pigment optical density with objective and subjective perimetry and visual acuity in age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- In Vivo Correlation Between Macular Pigment Optical Volume and Retinal Layers Thickness.Investigative ophthalmology & visual science · 2024Observational
- Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population.Investigative ophthalmology & visual science · 2021Article
- Article
- Are Current Methods of Measuring Dark Adaptation Effective in Detecting the Onset and Progression of Age-Related Macular Degeneration? A Systematic Literature Review.Ophthalmology and therapy · 2021Review
- Predictors of macular pigment and contrast threshold in Spanish healthy normolipemic subjects (45-65 years) with habitual food intake.PloS one · 2021Article
- Local Abundance of Macular Xanthophyll Pigment Is Associated with Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2020Article
- Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases.Oxidative medicine and cellular longevity · 2019Review
- Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy.Journal of biomedical optics · 2018Review
- Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) of Macular Pigment.Investigative ophthalmology & visual science · 2018Article
- What do we know about the macular pigment in AMD: the past, the present, and the future.Eye (London, England) · 2018Review
- Macular pigment optical density and visual quality of life.Journal of optometryArticle
- Assessment of Macular Pigment Optical Density Using Fundus Reflectometry in Diabetic Patients.Middle East African journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD).
methods121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). MP was measured using customised heterochromatic flicker photometry.
resultsLetter CS, mesopic and photopic CS, photopic GD and mean reading speed were each significantly (p<0.05) associated with MP across a range of retinal eccentricities, and these statistically significant relationships persisted after controlling for age, sex and cataract grade. BCVA, NEI VFQ-25 score, PRT and mesopic GD were unrelated to MP after controlling for age, sex and cataract grade (p>0.05, for all).
conclusionsMP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. TRIAL REGISTRATION NUMBER: ISRCTN13894787.
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Registered trials
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