ArticleDevelopmental biology2017
Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- A retinoic acid-Rfx6 cascade modulates Wnt/Bmp-dependent gut tube patterning: insight into the molecular basis of Mitchell-Riley Syndrome.Development (Cambridge, England) · 2026Article
- Growth-regulating proteins differ between British seawater fish species, shedding light on their ecological adaptations.Journal of fish biology · 2026Article
- The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus.Developmental cell · 2023Article
- Gain of gene regulatory network interconnectivity at the origin of vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration.Developmental biology · 2022Article
- The Organizer and Its Signaling in Embryonic Development.Journal of developmental biology · 2021Review
- Rab7 is required for mesoderm patterning and gastrulation in Xenopus.Biology open · 2021Article
- Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification.Scientific reports · 2021Article
- Pinhead antagonizes Admp to promote notochord formation.iScience · 2021Article
- Control of zygotic genome activation in Xenopus.Current topics in developmental biology · 2021Review
- A 'tad' of hope in the fight against airway disease.Biochemical Society transactions · 2020Review
- Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway.Development (Cambridge, England) · 2020Article
- Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network.eLife · 2020Article
- Chromatin accessibility and histone acetylation in the regulation of competence in early development.Developmental biology · 2020Article
- Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer.eLife · 2020Article
- ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia.Cell reports · 2019Article
- Integration of Wnt and FGF signaling in theDevelopment (Cambridge, England) · 2019Article
- Znf703 is a novel RA target in the neural plate border.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which then activates target genes. However, few targets of this signaling pathway that mediate early developmental processes are known. Here we sought to identify transcriptional targets of the Wnt/β-catenin signaling pathway using a genome-wide approach. We selected putative targets using the criteria of reduced expression upon zygotic Wnt knockdown, β-catenin binding within 50kb of the gene, and expression in tissues that receive Wnt signaling. Using these criteria, we found 21 novel direct transcriptional targets of Wnt/β-catenin signaling during gastrulation and in addition have identified putative regulatory elements for further characterization in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.