Evidence map›Paper›PMID 27091719›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts.

Pierre Orban, Martin Desseilles, Adrianna Mendrek, Josiane Bourque, Pierre Bellec, Emmanuel Stip

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  6. Article
  7. Article
  8. Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pierre OrbanFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).
Martin DesseillesFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).
Adrianna MendrekFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).
Josiane BourqueFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).
Pierre BellecFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).
Emmanuel StipFrom the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Orban); the Department of Psychology, Faculty of Medicine, University of Namur, Belgium (Desseilles); the Department of Psychology, Bishop's University, Sherbrooke, Que., Canada (Mendrek); the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Bourque); the Department of Computer Sciences and Operational Research, Université de Montréal, Montreal, Que., Canada (Bellec); and the Department of Psychiatry, Université de Montréal, Montreal, Que., Canada (Stip).

Funding

CIHR
6 · The paper itself

Abstract

backgroundSchizophrenia has been defined as a dysconnection syndrome characterized by aberrant functional brain connectivity. Using task-based fMRI, we assessed to what extent the nature of the cognitive context may further modulate abnormal functional brain connectivity.

methodsWe analyzed data matched for motion in patients with schizophrenia and healthy controls who performed 3 different tasks. Tasks 1 and 2 both involved emotional processing and only slighlty differed (incidental encoding v. memory recognition), whereas task 3 was a much different mental rotation task. We conducted a connectome-wide general linear model analysis aimed at identifying context-dependent and independent functional brain connectivity alterations in patients with schizophrenia.

resultsAfter matching for motion, we included 30 patients with schizophrenia and 30 healthy controls in our study. Abnormal connectivity in patients with schizophrenia followed similar patterns regardless of the degree of similarity between cognitive tasks. Decreased connectivity was most notable in the medial prefrontal cortex, the anterior and posterior cingulate, the temporal lobe, the lobule IX of the cerebellum and the premotor cortex. LIMITATIONS: A more circumscribed yet significant context-dependent effect might be detected with larger sample sizes or cognitive domains other than emotional and visuomotor processing.

conclusionThe context-independence of functional brain dysconnectivity in patients with schizophrenia provides a good justification for pooling data from multiple experiments in order to identify connectivity biomarkers of this mental illness.

Indexed as

AdultBrainCognitionConnectomeEmotionsFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsRecognition, PsychologyRotationSchizophreniaSchizophrenic Psychology

Identifiers

PMID27091719
PMCPMC5373708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.