SynthesisTropical medicine & international health : TM & IH2016
Mortality risk and associated factors in HIV-exposed, uninfected children.
Synthesis in Tropical medicine & international health : TM & IH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Co-trimoxazole prophylaxis for children who are HIV-exposed and uninfected: a systematic review.Journal of the International AIDS Society · 2023Pooled it
- Pasteurised donor human milk for HIV-exposed infants in Saskatchewan, Canada: a feasibility trial protocol.BMJ open · 2026Article
- Associations between maternal lipid profiles and cardiovascular and metabolic outcomes among children who are HIV-exposed uninfected vs. HIV-unexposed children aged 5-8 years in a South African birth cohort.AIDS (London, England) · 2026Article
- Integration of Preclinical and Clinical Vaccine Safety and Immunogenicity Testing for Development of a Pediatric HIV Vaccine to Achieve Protective HIV Immunity Prior to Adolescence.Current HIV research · 2026Review
- Review
- Altered milk tryptophan and tryptophan metabolites in women living with HIV.Nature communications · 2025Article
- Risk of hospitalization or death does not differ in children exposed to HIV, yet uninfected compared to nonexposed peers in Lusaka, Zambia.AIDS (London, England) · 2025Article
- Outcomes of HIV-exposed infected and HIV-exposed uninfected children admitted to two paediatric intensive care units in South Africa: A retrospective analytical cohort study.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- Residency as a determinant of oral health disparities in primary dentition among HIV-infected, HIV-exposed, and unexposed children in Kenya - findings from a cohort study.Critical public health · 2025Article
- Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected?PLOS global public health · 2025Review
- Care of the Child Perinatally Exposed to Human Immunodeficiency Virus.Clinics in perinatology · 2024Review
- The Negative Impact of Maternal HIV Infection on Birth Outcomes-Myth or Reality?Pathogens (Basel, Switzerland) · 2024Article
- Risk and rates of hospitalisation in young children: A prospective study of a South African birth cohort.PLOS global public health · 2024Article
- Effects of Maternal HIV Infection on Early Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Kenyan Mother-Infant Cohort.The Journal of infectious diseases · 2023Article
- When and how to intervene to improve the health of children born HIV-free.Journal of the International AIDS Society · 2023Article
- Setting the research agenda: involving parents in research on children who are HIV-free.Journal of the International AIDS Society · 2023Article
- Article
- A 12-month Prospective Study of HIV-infected and HIV-uninfected Women and Their Infants in Malawi: Comparative Analysis of Clinical Events and Infant Growth.The American journal of tropical medicine and hygiene · 2023Article
- Morbidity and Mortality of HIV-Exposed Uninfected Infants in a Tertiary Referral Facility in Yaoundé, Cameroon.International journal of MCH and AIDS · 2023Article
- HIV-Associated Alterations of the Biophysical Features of Maternal Antibodies Correlate With Their Reduced Transfer Across the Placenta.The Journal of infectious diseases · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveWith increasing maternal antiretroviral treatment (ART), the number of children newly infected with HIV has declined. However, the possible increased mortality in the large number of HIV-exposed, uninfected (HEU) children may be of concern. We quantified mortality risks among HEU children and reviewed associated factors.
methodsSystematic search of electronic databases (PubMed, Scopus). We included all studies reporting mortality of HEU children to age 60 months and associated factors. Relative risk of mortality between HEU and HIV-unexposed, uninfected (HUU) children was extracted where relevant. Inverse variance methods were used to adjust for study size. Random-effects models were fitted to obtain pooled estimates.
resultsA total of 14 studies were included in the meta-analysis and 13 in the review of associated factors. The pooled cumulative mortality in HEU children was 5.5% (95% CI: 4.0-7.2; I(2) = 94%) at 12 months (11 studies) and 11.0% (95% CI: 7.6-15.0; I(2) = 93%) at 24 months (four studies). The pooled risk ratios for the mortality in HEU children compared to HUU children in the same setting were 1.9 (95% CI: 0.9-3.8; I(2) = 93%) at 12 months (four studies) and 2.4 (95% CI: 1.1-5.1; I(2) = 93%) at 24 months (three studies).
conclusionCompared to HUU children, mortality risk in HEU children was about double at both age points, although the association was not statistically significant at 12 months. Interpretation of the pooled estimates is confounded by considerable heterogeneity between studies. Further research is needed to characterise the impact of maternal death and breastfeeding on the survival of HEU infants in the context of maternal ART, where current evidence is limited.
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