ArticleSchizophrenia research2016
Validation of a Computerized test of Functional Capacity.
Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Exploring the Relationship between Cognitive Performance, Performance-Based Functioning, and Everyday Functioning in People with Schizophrenia: a Systematic Literature Review.Schizophrenia bulletin · 2026Pooled it
- A systematic review of performance-based functional capacity measures for use in Huntington's disease and evaluation of their suitability for clinical trials.Journal of Huntington's disease · 2025Pooled it
- Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force.Bipolar disorders · 2017Guideline
- A phase 2 randomized controlled trial of luvadaxistat in treatment of adults with cognitive impairment associated with schizophrenia: results from the ERUDITE study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Computerized Cognitive and Skills Training in Older People With Mild Cognitive Impairment: Using Ecological Momentary Assessment to Index Treatment-Related Changes in Real-World Performance of Technology-Dependent Functional Tasks.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Trial
- Online Social Cognition Training in Schizophrenia: A Double-Blind, Randomized, Controlled Multi-Site Clinical Trial.Schizophrenia bulletin · 2021Trial
- A process-oriented functional capacity assessment: First application of the neuropsychological evaluation of the UPSA (NEUPSA).Applied neuropsychology. Adult · 2026Article
- Validation of the virtual reality functional capacity assessment tool (VRFCAT) in a Spanish sample of individuals with psychosis and healthy controls.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Validation and normative data for the BAC app in Spanish-speaking individuals with psychosis and healthy controls.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Efficacy and safety of iclepertin (BI 425809) with adjunctive computerized cognitive training in patients with schizophrenia.Schizophrenia research. Cognition · 2025Article
- Assessing the inter-rater reliability of the Schizophrenia Cognition Rating Scale: a non-interventional quantitative study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Considerations for Streamlining the Pathway Toward Approval of a Cognition Enhancer for Schizophrenia.Schizophrenia bulletin · 2025Review
- Towards Enhancing Drug Development Methodology to Treat Cognitive Impairment Associated With Schizophrenia and Other Neuropsychiatric Conditions: Insights From 2 Decades of Clinical Trials.Schizophrenia bulletin · 2025Review
- Migration of digital functional capacity assessments from device resident to cloud-based delivery: Development and convergent validity.Schizophrenia research. Cognition · 2025Article
- Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders.NPP - digital psychiatry and neuroscience · 2025Article
- Treatment of cognitive deficits in schizophrenia using a new technique of Cognitive Training in Virtual Reality: a pilot study.Health psychology research · 2025Article
- Current limitations in technology-based cognitive assessment for severe mental illnesses: a focus on feasibility, reliability, and ecological validity.Frontiers in behavioral neuroscience · 2025Review
- Location-based differences in cognition and functional capacity: Consistent levels of impairment in participants with schizophrenia compared to healthy controls.Psychiatry research · 2024Article
- Adjunctive methylphenidate extended release in patients with schizophrenia: Protocol of a single-centre fixed dose cross-over open-label trial to improve functional and cognitive outcomes.Contemporary clinical trials communications · 2024Article
- Improvements in performance based measures of functional capacity and cognition after computerized functional skills training in older people with mild cognitive impairment and healthy comparators.Psychiatry research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Regulatory guidance for schizophrenia cognition clinical trials requires that the assessment of cognitive change is accompanied by a functionally meaningful endpoint. However, currently available measures are challenged by resistance to change, psychometric weaknesses, and for interview-based assessments, dependence upon the presence of an informant. The aims of the current study were to: 1) assess the validity, sensitivity, and reliability of the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) as a measure of functional capacity; 2) determine the association between performance on the VRFCAT and performance on the MATRICS Consensus Cognitive Battery (MCCB); and 3) compare the metrics of the VRFCAT with the UCSD Performance-based Skills Assessment (UPSA). 167 patients with schizophrenia and 166 healthy controls completed the VRFCAT, UPSA, and the MCCB at baseline. The VRFCAT and UPSA were completed again at follow-up. The VRFCAT, MCCB, and UPSA were very sensitive to impairment in schizophrenia (d=1.16 to 1.22). High test-retest reliability was demonstrated for VRFCAT total completion time and the UPSA total score in patients (ICC=0.81 and 0.78, respectively). The UPSA demonstrated significant practice effects in patients (d=0.35), while the VRFCAT did not (d=-0.04). VRFCAT total completion time was correlated with both UPSA (r=-0.56, p<0.0001 for patients and -0.58, p<0.0001 for controls) and MCCB Composite (r=-0.57, p<0.0001 for patients and -0.68, p<0.0001 for controls). The VRFCAT is a highly reliable and sensitive measure of functional capacity with associations to the UPSA and MCCB. These results provide encouraging support for a computerized functional capacity assessment for use in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.