ArticleClinical rheumatology2016
The relationship between femoral cartilage thickness and muscle strength in knee osteoarthritis.
Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07657481 (Comparison of the Effects of Two Different Home Exercise Programs on Femoral Cartilage Thickness and Clinical Parameters in Individuals With Knee Osteoarthritis), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effects of Two Different Home Exercise Programs on Femoral Cartilage Thickness and Clinical Parameters in Individuals With Knee Osteoarthritis: A Randomized Controlled Trial
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hip abductor strengthening in patients diagnosed with knee osteoarthritis - a systematic review and meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- Evaluation of the effect of high-intensity laser therapy (HILT) on function, muscle strength, range of motion, pain level, and femoral cartilage thickness in knee osteoarthritis: randomized controlled study.Lasers in medical science · 2023Trial
- Efficacy of high intensity laser therapy in knee osteoarthritis: a double-blind controlled randomized study.Clinical rheumatology · 2021Trial
- Improvements in hip stability and knee muscle strength after a single-dose platelet-rich plasma injection combined with exercise in women with knee osteoarthritis.Irish journal of medical science · 2026Article
- Ultrasound findings in patients with knee osteoarthritis: Relationships with clinical characteristics, radiographic findings and generalized osteoarthritis.Osteoarthritis and cartilage open · 2025Article
- Open Versus Closed Kinetic Chain: Exercise Effects on Center of Pressure and Y-Balance in Middle-Aged Women with Knee Osteoarthritis-A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Relationship Between Sarcopenia, Femoral Cartilage Thickness, and Knee Osteoarthritis: Case-Control Study.International journal of rheumatic diseases · 2025Article
- Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player.Frontiers in endocrinology · 2025Review
- Differences in ankle and knee muscle architecture and plantar pressure distribution among women with knee osteoarthritis.Journal of foot and ankle research · 2024Article
- Article
- Comparison of the Effects of Isokinetic, Isometric, and Isotonic Exercises on Knee Osteoarthritis Using Ultrasound.Cureus · 2022Article
- Sex-Specific Associations between Cartilage Structure and Metabolism at Rest and Acutely Following Walking and Drop-Landing.Cartilage · 2021Article
- Changes in anterior femoral articular cartilage structure in collegiate rugby athletes with and without a history of traumatic knee joint injury following a five-month competitive season.Scientific reports · 2021Observational
- Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?The journal of knee surgery · 2020Review
- Comparison of medial femoral cartilage deformation in normal adults according to gait conditions.Journal of exercise rehabilitation · 2019Article
- Effects of isokinetic muscle strengthening on balance, proprioception, and physical function in bilateral knee osteoarthritis patients with moderate fall risk.Turkish journal of physical medicine and rehabilitation · 2018Article
- Ultrasonographic Assessment of Femoral Cartilage in Individuals With Anterior Cruciate Ligament Reconstruction: A Case-Control Study.Journal of athletic training · 2018Article
- Development of a questionnaire survey to evaluate lower limb function of patients with knee osteoarthritis.Clinical rheumatology · 2018Article
- [Research progress of rehabilitation after autologous chondrocyte implantation on knee].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore whether femoral cartilage thickness is related (and changes) with muscle strength in subjects with knee osteoarthritis (OA). Forty patients (27 F, 13 M) with knee OA-who were under quadriceps muscle strengthening program-were enrolled in the study. Isokinetic/isometric knee muscle strength measurements (at 30-60° angles and 60-180° velocity) were performed at baseline, end of the muscle strengthening program, and third month control visit using a biodex dynamometer. Femoral cartilage thicknesses (at medial/lateral condyle and intercondylar area) were measured using ultrasonography. Seventy-nine knees of 40 patients (27 F, 13 M) aged 52.03 ± 11.72 years (range, 26-71) were analyzed. Mean VAS scores on the first and third months were significantly lower than the initial values (p < 0.001, p = 0.049). Isometric peak torque and total work values at 180 °/s were significantly higher than the baseline measurements at first and third month controls (all p < 0.05). Cartilage thicknesses (at three sites) were significantly higher than the baseline measurements (all p < 0.05) on the third month but not on the first month (all p > 0.05). Femoral cartilage thicknesses were positively correlated with isometric strength values at baseline and third month. We propose that femoral cartilage thicknesses increase on the third month of strengthening therapy. Since this late-phase thickening parallels the earlier increase in muscle strength (starting, on the first month), we speculate that regeneration rather than edema might be the primary underlying cause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.