ArticleInternational urogynecology journal2016
Comparative histology of mouse, rat, and human pelvic ligaments.
Article in International urogynecology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Aging of Pelvic Floor in Animal Models: A Sistematic Review of Literature on the Role of the Extracellular Matrix in the Development of Pelvic Floor Prolapse.Frontiers in medicine · 2022Pooled it
- Animal models for pelvic organ prolapse: systematic review.International urogynecology journal · 2021Pooled it
- Article
- The Development of the Human Female Reproductive Tract. Part 1: Uterine Tube and Uterus.Clinical anatomy (New York, N.Y.) · 2026Article
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- New Rat Model Mimicking Sacrocolpopexy for POP Treatment and Biomaterials Testing via Unilateral Presacral Suspension.International urogynecology journal · 2025Article
- Animal models of postpartum hemorrhage.Lab animal · 2024Review
- Establishing a Rat Model of Pelvic Organ Prolapse with All Compartment Defects by Persistent Cervical Tension.International urogynecology journal · 2024Article
- The Role of Botulinum Neurotoxin A in the Conservative Treatment of Fractures: An Experimental Study on Rats.TheScientificWorldJournal · 2024Article
- Supramolecular Fibrous Hydrogel Augmentation of Uterosacral Ligament Suspension for Treatment of Pelvic Organ Prolapse.Advanced healthcare materials · 2023Article
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Ex Vivo Uniaxial Tensile Properties of Rat Uterosacral Ligaments.Annals of biomedical engineering · 2023Article
- Morphological features of the mouse duodenocolic fold in foetus and adult.Journal of anatomy · 2022Article
- The Action of Botulinum Toxin A on the Sternocleidomastoid Muscle: An Experimental Study on Rats.TheScientificWorldJournal · 2022Article
- Mechanics of Uterosacral Ligaments: Current Knowledge, Existing Gaps, and Future Directions.Annals of biomedical engineering · 2021Review
- Mechanical Analysis of the Uterosacral Ligament: Swine vs. Human.Annals of biomedical engineering · 2018Article
- Female pelvic floor biomechanics: bridging the gap.Current opinion in urology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe uterosacral (USL) and cardinal ligaments (CL) provide support to the uterus and pelvic organs, and the round ligaments (RL) maintain their position in the pelvis. In women with pelvic organ prolapse (POP), the connective tissue, smooth muscle, vasculature, and innervation of the pelvic support structures are altered. Rodents are commonly used animal models for POP research. However, the pelvic ligaments have not been defined in these animals. In this study, we hypothesized that the gross anatomy and histological composition of pelvic ligaments in rodents and humans are similar.
methodsWe performed an extensive literature search for anatomical and histological descriptions of the pelvic support ligaments in rodents. We also performed anatomical dissections of the pelvis to define anatomical landmarks in relation to the ligaments. In addition, we identified the histological components of the pelvic ligaments and performed quantitative analysis of the smooth muscle bundles and connective tissue of the USL and RL.
resultsThe anatomy of the USL, CL, and RL and their anatomical landmarks are similar in mice, rats, and humans. All species contain the same cellular components and have similar histological architecture. However, the cervical portion of the mouse USL and RL contain more smooth muscle and less connective tissue compared with rat and human ligaments.
conclusionThe pelvic support structures of rats and mice are anatomically and histologically similar to those of humans. We propose that both mice and rats are appropriate, cost-effective models for directed studies in POP research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.