ArticleSleep2016
Circadian Rest-Activity Rhythm in Pediatric Type 1 Narcolepsy.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Current and Emerging Therapies for Pediatric Sleep Disorders: A Narrative Review.Neurology and therapy · 2026Review
- Present and Future of Central Disorders of Hypersomnolence.Journal of sleep research · 2025Review
- Pediatric sleep movements: a review of methodologies, normative data, disease associations, and research gaps.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Role of Daytime Continuous Polysomnography in the Diagnosis of Pediatric Narcolepsy Type 1.Neurology · 2024Article
- Circadian rhythm of daytime sleepiness in pediatric narcolepsy: A pilot study.Brain and behavior · 2023Article
- Impact of intermittently scanned continuous glucose monitoring with alarms on sleep and metabolic outcomes in children and adolescents with type 1 diabetes.Acta diabetologica · 2022Observational
- Pediatric Narcolepsy-A Practical Review.Children (Basel, Switzerland) · 2022Review
- The importance of social zeitgeber in paediatric type 1 narcolepsy: What we can learn from the COVID-19 restrictions adopted in Italy?Journal of sleep research · 2022Article
- Current Understanding of Narcolepsy 1 and its Comorbidities: What Clinicians Need to Know.Advances in therapy · 2022Review
- Disrupted nighttime sleep and sleep instability in narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- The influence of antidepressants and actigraphy-derived sleep characteristics on pediatric multiple sleep latency testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Case Report: Burden of Illness in Narcolepsy Type 1: Hikikomori in a Teenage Girl.Frontiers in psychology · 2021Article
- Excessive daytime sleepiness in narcolepsy and central nervous system hypersomnias.Sleep & breathing = Schlaf & Atmung · 2020Review
- A Pilot Study on Circadian Activity Rhythm in Pediatric Attention-Deficit Hyperactivity Disorder.Clocks & sleep · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesPediatric type 1 narcolepsy is often challenging to diagnose and remains largely undiagnosed. Excessive daytime sleepiness, disrupted nocturnal sleep, and a peculiar phenotype of cataplexy are the prominent features. The knowledge available about the regulation of circadian rhythms in affected children is scarce. This study compared circadian rest-activity rhythm and actigraphic estimated sleep measures of children with type 1 narcolepsy versus healthy controls.
methodsTwenty-two drug-naïve type 1 narcolepsy children and 21 age- and sex- matched controls were monitored for seven days during the school week by actigraphy. Circadian activity rhythms were analyzed through functional linear modeling; nocturnal and diurnal sleep measures were estimated from activity using a validated algorithm.
resultsChildren with type 1 narcolepsy presented an altered rest-activity rhythm characterized by enhanced motor activity throughout the night and blunted activity in the first afternoon. No difference was found between children with type 1 narcolepsy and controls in the timing of the circadian phase. Actigraphic sleep measures showed good discriminant capabilities in assessing type 1 narcolepsy nycthemeral disruption.
conclusionsActigraphy reliably renders the nycthemeral disruption typical of narcolepsy type 1 in drug-naïve children with recent disease onset, indicating the sensibility of actigraphic assessment in the diagnostic work-up of childhood narcolepsy type 1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.