ArticleSleep2016
Temporal Organization of the Sleep-Wake Cycle under Food Entrainment in the Rat.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of a Hedonic Stimulus on the Sleep Architecture of Male Wistar Rats.Sleep science (Sao Paulo, Brazil) · 2023Article
- Effect of Restricted Feeding on Metabolic Health and Sleep-Wake Rhythms in Aging Mice.Frontiers in neuroscience · 2021Article
- Eat, sleep, repeat: the role of the circadian system in balancing sleep-wake control with metabolic need.Current opinion in physiology · 2020Review
- Article
- Insomnia in Adolescence.Medical sciences (Basel, Switzerland) · 2018Review
- Cortical region-specific sleep homeostasis in mice: effects of time of day and waking experience.Sleep · 2018Article
- Effects of Social Defeat Stress on Sleep in Mice.Frontiers in behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo analyze the temporal organization of the sleep-wake cycle under food entrainment in the rat.
methodsEighteen male Sprague-Dawley rats were chronically implanted for polysomnographic recording. During the baseline (BL) protocol, rats were recorded under a 12:12 light-dark (LD) schedule in individual isolation chambers with food and water ad libitum. Food entrainment was performed by means of a 4-h food restriction (FR) protocol starting at photic zeitgeber time 5. Eight animals underwent a 3-h phase advance of the FR protocol (A-FR). We compared the mean curves and acrophases of wakefulness, NREM sleep, and REM sleep under photic and food entrainment and after a phase advance in scheduled food delivery. We further evaluated the dynamics of REM sleep homeostasis and the NREM sleep EEG delta wave profile.
resultsA prominent food-anticipatory arousal interval was observed after nine or more days of FR, characterized by increased wakefulness and suppression of REM sleep propensity and dampening of NREM sleep EEG delta activity. REM sleep exhibited a robust nocturnal phase preference under FR that was not explained by a nocturnal REM sleep rebound. The mean curve of sleep-wake states and NREM sleep EEG delta activity remained phase-locked to the timing of meals during the A-FR protocol.
conclusionsOur results support the hypothesis that under food entrainment, the sleep-wake cycle is coupled to a food-entrainable oscillator (FEO). Our findings suggest an unexpected interaction between FEO output and NREM sleep EEG delta activity generators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.