ArticleScientific reports2016
Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Alexithymia and self-harm in depressed adolescents: the mediating role of resting-state functional connectivity of the ventral hippocampal-fusiform gyrus.Annals of general psychiatry · 2026Article
- Transcranial Alternating Current Stimulation as an Adjuvant for Nonfluent Aphasia: A Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2026Article
- Dynamic network dysregulation in post-stroke aphasia: analysis of dALFF and dynamic functional connectivity.BMC medical imaging · 2026Article
- Dynamic functional reorganization in post-stroke aphasia: a state-of-the-art fMRI review from disease evolution to intervention.Frontiers in neuroscience · 2026Review
- Test-retest reliability of edge-level resting-state functional connectivity in people with aphasia.Neuroimage. Reports · 2025Article
- Unveiling Cognitive Interference: fNIRS Insights Into Poststroke Aphasia During Stroop Tasks.Neural plasticity · 2025Article
- Network-based statistics distinguish anomic and Broca's aphasia.Brain structure & function · 2024Article
- Defining Trajectories of Linguistic, Cognitive-Communicative, and Quality of Life Outcomes in Aphasia: Longitudinal Observational Study Protocol.Archives of rehabilitation research and clinical translation · 2024Article
- Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study.Brain sciences · 2023Article
- Resting-State Neural-Activity Alterations in Subacute Aphasia after Stroke.Brain sciences · 2022Article
- Increased cortical-medulla functional connectivity is correlated with swallowing in dysphagia patients with subacute infratentorial stroke.NeuroImage. Clinical · 2022Article
- Multivariate machine learning-based language mapping in glioma patients based on lesion topography.Brain imaging and behavior · 2021Article
- Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.Brain : a journal of neurology · 2020Article
- Altered dynamics of brain segregation and integration in poststroke aphasia.Human brain mapping · 2019Article
- Lower Limb Task-Based Functional Connectivity Is Altered in Stroke.Brain connectivity · 2019Article
- Reorganization of cerebro-cerebellar circuit in patients with left hemispheric gliomas involving language network: A combined structural and resting-state functional MRI study.Human brain mapping · 2018Article
- Contributions of Neuroimaging to Understanding Language Deficits in Acute Stroke.Seminars in speech and language · 2018Review
- Functional Connectivity Alterations in Children with Spastic and Dyskinetic Cerebral Palsy.Neural plasticity · 2018Article
- Observational
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.
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