ArticleBiochemical and biophysical research communications2016
Epstein-Barr virus latency type and spontaneous reactivation predict lytic induction levels.
Article in Biochemical and biophysical research communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026Review
- Article
- Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.bioRxiv : the preprint server for biology · 2025Article
- Single-Cell Transcriptomics of Epstein-Barr Virus and Human Herpesvirus 6 Coinfection.Microbiology resource announcements · 2023Article
- Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.PLoS pathogens · 2023Article
- Mechanisms of T cell evasion by Epstein-Barr virus and implications for tumor survival.Frontiers in immunology · 2023Review
- Pathogenesis and therapeutic implications of EBV-associated epithelial cancers.Frontiers in oncology · 2023Review
- The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.American journal of human genetics · 2022Article
- Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy.Tumour virus research · 2022Review
- The BHLF1 Locus of Epstein-Barr Virus Contributes to Viral Latency and B-Cell Immortalization.Journal of virology · 2020Article
- The Epstein-Barr virus LMP1 interactome: biological implications and therapeutic targets.Future virology · 2018Article
- The Structure-To-Function Relationships of Gammaherpesvirus-Encoded Long Non-Coding RNAs and Their Contributions to Viral Pathogenesis.Non-coding RNA · 2018Review
- Curcuminoids as EBV Lytic Activators for Adjuvant Treatment in EBV-Positive Carcinomas.Cancers · 2018Article
- The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during Reactivation.Journal of virology · 2018Article
- RNA-seq detects pharmacological inhibition of Epstein-Barr virus late transcription during spontaneous reactivation.Genomics data · 2017Article
- Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps.The Journal of biological chemistry · 2017Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The human Epstein-Barr virus (EBV) evades the immune system by entering a transcriptionally latent phase in B cells. EBV in tumor cells expresses distinct patterns of genes referred to as latency types. Viruses in tumor cells also display varying levels of lytic transcription resulting from spontaneous reactivation out of latency. We measured this dynamic range of lytic transcription with RNA deep sequencing and observed no correlation with EBV latency types among genetically different viruses, but type I cell lines reveal more spontaneous reactivation than isogenic type III cultures. We further determined that latency type and spontaneous reactivation levels predict the relative amount of induced reactivation generated by cytotoxic chemotherapy drugs. Our work has potential implications for personalizing medicine against EBV-transformed malignancies. Identifying latency type or measuring spontaneous reactivation may provide predictive power in treatment contexts where viral production should be either avoided or coerced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.