Evidence map›Paper›PMID 27091300›Full record

ArticleBehavioural brain research2016

Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats.

Alicia Izquierdo, Hilda Pozos, Adrianna De La Torre, Simone DeShields, James Cevallos, Jonathan Rodriguez, Alexandra Stolyarova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alicia IzquierdoDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA; Integrative Center for Addictions, University of California at Los Angeles, Los Angeles, CA, USA; Integrative Center for Learning and Memory, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address: aizquie@psych.ucla.edu.
Hilda PozosDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Adrianna De La TorreDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Simone DeShieldsDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
James CevallosDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Jonathan RodriguezDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Alexandra StolyarovaDepartment of Psychology, The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

Corticostriatal circuitry supports flexible reward learning and emotional behavior from the critical neurodevelopmental stage of adolescence through adulthood. It is still poorly understood how prescription drug exposure in adolescence may impact these outcomes in the long-term. We studied adolescent methylphenidate (MPH) and fluoxetine (FLX) exposure in rats and their impact on learning and emotion in adulthood. In Experiment 1, male and female rats were administered MPH, FLX, or saline (SAL), and compared with methamphetamine (mAMPH) treatment beginning in postnatal day (PND) 37. The rats were then tested on discrimination and reversal learning in adulthood. In Experiment 2, animals were administered MPH or SAL also beginning in PND 37 and later tested in adulthood for anxiety levels. In Experiment 3, we analyzed striatal dopamine D1 and D2 receptor expression in adulthood following either extensive learning (after Experiment 1) or more brief emotional measures (after Experiment 2). We found sex differences in discrimination learning and attenuated reversal learning after MPH and only sex differences in adulthood anxiety. In learners, there was enhanced striatal D1, but not D2, after either adolescent MPH or mAMPH. Lastly, also in learners, there was a sex x treatment group interaction for D2, but not D1, driven by the MPH-pretreated females, who expressed significantly higher D2 levels compared to SAL. These results show enduring effects of adolescent MPH on reversal learning in rats. Developmental psychostimulant exposure may interact with learning to enhance D1 expression in adulthood, and affect D2 expression in a sex-dependent manner.

Indexed as

Sex CharacteristicsAge FactorsAnimalsAnimals, NewbornCentral Nervous System StimulantsConditioning, OperantCorpus StriatumDopamine Uptake InhibitorsDose-Response Relationship, DrugFemaleFluoxetineLearningMaleMethamphetamineMethylphenidateRatsCentral Nervous System StimulantsDopamine Uptake InhibitorsFluoxetineMethamphetamineMethylphenidateReceptors, Dopamine D1Receptors, Dopamine D2Selective Serotonin Reuptake InhibitorsAnxietyDopamine receptorsPsychostimulantsReversal learningSexStriatum

Identifiers

PMID27091300
PMCPMC4946635
OpenAlexW2344331142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.