Evidence map›Paper›PMID 27091028›Full record

ArticleAIDS and behavior2016

Substance Use and Adherence Among People Living with HIV/AIDS Receiving cART in Latin America.

Raquel B De Boni, Bryan E Shepherd, Beatriz Grinsztejn, Carina Cesar, Claudia Cortés, Denis Padgett, Eduardo Gotuzzo, Pablo F Belaunzarán-Zamudio, Peter F Rebeiro, Stephany N Duda and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in AIDS and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  10. HIV and Substance Use in Latin America: A Scoping Review.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Raquel B De BoniInstituto Nacional de Infectologia Evandro Chagas - FIOCRUZ, Av. Brasil 4365, Rio de Janeiro, CEP 21040-360, Brazil. raqueldeboni@gmail.com.
Bryan E ShepherdVanderbilt University, Nashville, USA.
Beatriz GrinsztejnInstituto Nacional de Infectologia Evandro Chagas - FIOCRUZ, Av. Brasil 4365, Rio de Janeiro, CEP 21040-360, Brazil.
Carina CesarFundación Huésped, Buenos Aires, Argentina.
Claudia CortésFundación Arriaran, Santiago, Chile.
Denis PadgettUniversidad Peruana Cayetano Heredia, Lima, Peru.
Eduardo GotuzzoInstituto Hondureno de Seguridad Social and Hospital Escuela, Tegucigalpa, Honduras.
Pablo F Belaunzarán-ZamudioDepartamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Peter F RebeiroVanderbilt University, Nashville, USA.
Stephany N DudaVanderbilt University, Nashville, USA.
Catherine C McGowanVanderbilt University, Nashville, USA.
Vanderbilt University · USFundação Oswaldo Cruz · BRFundacion Arriarán · CLFundación Huésped · ARInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXUniversidad Peruana Cayetano Heredia · PE

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)UM1AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI BEATRIZ GRINSZTEJN · 2012 to 2026
$26.3M
NIAID NIH HHS U01 AI069923NIAID NIH HHS UM1 AI069476
6 · The paper itself

Abstract

This cross-sectional study describes substance use prevalence and its association with combination antiretroviral therapy (cART) adherence among 3343 individuals receiving care at HIV clinics in Argentina, Brazil, Chile, Honduras, Mexico, and Peru. A rapid screening tool evaluated self-reported 7-day recall of alcohol, marijuana, cocaine, heroin, and methamphetamine use, and missed cART doses. Overall, 29.3 % individuals reported having ≥1 alcoholic drinks, 5.0 % reported any illicit drug use and 17.0 % reported missed cART doses. In the logistic regression model, compared to no substance use, alcohol use [adjusted odds ratio (AOR) = 2.46, 95 % confidence interval (CI): 1.99-3.05], illicit drug use (AOR = 3.57, 95 % CI: 2.02-6.30), and using both alcohol and illicit drugs (AOR = 4.98, 95 % CI: 3.19-7.79) were associated with missed cART doses. The associations between substance use and likelihood of missing cART doses point to the need of targeting alcohol and illicit drug use to improve adherence among people living with HIV in Latin America.

Indexed as

Illicit DrugsMedication AdherenceAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsCross-Sectional StudiesDrug Therapy, CombinationFemaleHIV InfectionsHumansLatin AmericaMaleMiddle AgedOdds RatioSubstance-Related DisordersAnti-HIV AgentsIllicit DrugsAdherenceHIV/AIDSLatin AmericaSubstance use

Identifiers

PMID27091028
PMCPMC5069110
OpenAlexW2336853675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.