SynthesisWorld neurosurgery2016
A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.
Synthesis in World neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Natural disease progression and novel survival prediction model for hepatocellular carcinoma with spinal metastases: a 10-year single-center study.World journal of surgical oncology · 2020Trial
- Bone metastases from hepatocellular carcinoma: Guidance on the management of spinal and long bone lesions.Journal of bone oncology · 2026Review
- Stereotactic radiosurgery for spinal cholangiocarcinoma metastases: Clinical outcomes and the role of biologically effective dose thresholds.Neurosurgical review · 2026Article
- Case Report: Thoracic spinal metastasis without definite intrahepatic recurrence after conversion therapy and hepatectomy for hepatocellular carcinoma.Frontiers in oncology · 2026Article
- Translaminar Screw Fixation for Giant C1 Lateral Mass Metastasis From Hepatocellular Carcinoma.Cureus · 2025Article
- Appendicular skeleton multiple bone metastasis as first manifestation of hepatocellular carcinoma.Radiology case reports · 2024Article
- Separation Operation Followed by Stereotactic Radiotherapy in the Treatment of Spinal Metastasis From Hepatocellular Carcinoma: A Retrospective Cohort Study.Global spine journal · 2024Article
- Improved oncologic outcomes by ablative radiotherapy in patients with bone metastasis from hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2021Article
- Article
- MYB Proto-oncogene-like 1-TWIST1 Axis Promotes Growth and Metastasis of Hepatocellular Carcinoma Cells.Molecular therapy oncolytics · 2020Article
- Spine stereotactic radiosurgery for metastases from hepatobiliary malignancies: patient selection using PRISM scoring.Journal of neuro-oncology · 2020Article
- Minimally Invasive Surgery without Decompression for Hepatocellular Carcinoma Spinal Metastasis with Epidural Spinal Cord Compression Grade 2.Journal of Korean Neurosurgical Society · 2019Article
- Surgical management of coincidental metastases to upper cervical spine and skull from hepatocellular carcinoma: a case report.The Journal of international medical research · 2018Article
- Treatment outcomes of patients with spinal metastases derived from hepatocellular carcinoma.International journal of clinical oncology · 2018Article
- Stress Hormone Cortisol Enhances Bcl2 Like-12 Expression to Inhibit p53 in Hepatocellular Carcinoma Cells.Digestive diseases and sciences · 2017Article
- Establishment of a Disease-Specific Graded Prognostic Assessment for Hepatocellular Carcinoma Patients with Spinal Metastasis.Gut and liver · 2017Article
- Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers - a series of 40 cases.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundHepatocellular carcinoma (HCC) frequently metastasizes to the spine. The impact of medical and/or surgical intervention on overall survival has been examined in a limited number of clinical studies, and herein we systematically review these data.
methodsWe performed a literature review using PubMed, Embase, CINAHL, and Web of Science to identify articles that reported survival, clinical outcomes, and/or prognostic factors associated with patients diagnosed with spinal metastases. The methodologic quality of each review was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool.
resultsThere were 26 articles (152 patients) that met the inclusion criteria and were treated with either surgery, radiotherapy, chemotherapy, and/or observation. There were 3 retrospective cohort studies, 17 case reports, 5 case series, and 1 longitudinal observational study. Of the patients with known overall survival after diagnosis of spinal metastasis, survival at 3 months, 6 months, 1 year, 2 years, and 5 years was 95.2%, 83.0%, 28.6%, 2.0%, and 1.4%, respectively. The median survival after diagnosis of the metastasis was 0.7 months in the patients who received no treatment, 7 months in the patients treated with surgical intervention alone, 6 months for patients who received chemotherapy and/or radiation, and 13.5 months in the patients treated with a combination of surgery and medical management. All other clinical or prognostic parameters were of low or insufficient strength.
conclusionsPatients diagnosed with HCC spinal metastasis have a 10.6-month overall survival. Further analysis of patients in prospective controlled trials will be essential to the development of treatment algorithms for these patients in the future.
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