ArticleJournal of neuro-oncology2016
Exploratory study of the effect of brain tumors on the default mode network.
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Article
- Changes on Cognition and Brain Network Temporal Variability After Pediatric Neurosurgery.Neurosurgery · 2025Article
- Presurgical structural connectivity predicts postsurgical cognitive impairment in glioma patients.Brain communications · 2025Article
- Functional connectotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients.Network neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Cognitive and cortical network alterations in pediatric temporal lobe space-occupying lesions: an fMRI study.Frontiers in human neuroscience · 2024Article
- Brain network mapping and glioma pathophysiology.Brain communications · 2023Review
- Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma.Scientific reports · 2022Article
- Neural Regulation of Cancer: Cancer-Induced Remodeling of the Central Nervous System.Advanced biology · 2022Review
- Effects of Different Scan Duration on Brain Effective Connectivity among Default Mode Network Nodes.Diagnostics (Basel, Switzerland) · 2022Article
- Widespread cortical functional disconnection in gliomas: an individual network mapping approach.Brain communications · 2022Article
- Dissociation of structural and functional connectomic coherence in glioma patients.Scientific reports · 2021Article
- Functional MRI Shows Altered Deactivation and a Corresponding Decrease in Functional Connectivity of the Default Mode Network in Patients with Gliomas.AJNR. American journal of neuroradiology · 2021Article
- Surface-Based Connectivity Integration: An atlas-free approach to jointly study functional and structural connectivity.Human brain mapping · 2021Article
- Asymmetric tumor-related alterations of network-specific intrinsic functional connectivity in glioma patients.Human brain mapping · 2020Article
- Review
- Alterations of white matter integrity associated with cognitive deficits in patients with glioma.Brain and behavior · 2020Article
- Altered hemodynamics contribute to local but not remote functional connectivity disruption due to glioma growth.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting state functional magnetic resonance imaging (RS-fMRI) is a popular method of visualizing functional networks in the brain. One of these networks, the default mode network (DMN), has exhibited altered connectivity in a variety of pathological states, including brain tumors. However, very few studies have attempted to link the effect of tumor localization, type and size on DMN connectivity. We collected RS-fMRI data in 73 patients with various brain tumors and attempted to characterize the different effects these tumors had on DMN connectivity based on their location, type and size. This was done by comparing the tumor patients with healthy controls using independent component analysis (ICA) and seed based analysis. We also used a multi-seed approach described in the paper to account for anatomy distortion in the tumor patients. We found that tumors in the left hemisphere had the largest effect on DMN connectivity regardless of their size and type, while this effect was not observed for right hemispheric tumors. Tumors in the cerebellum also had statistically significant effects on DMN connectivity. These results suggest that DMN connectivity in the left side of the brain may be more fragile to insults by lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.