SynthesisThe Cochrane database of systematic reviews2016
Urinary alkalisation for symptomatic uncomplicated urinary tract infection in women.
Synthesis in The Cochrane database of systematic reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Natural history of uncomplicated urinary tract infection without antibiotics: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Pooled it
- Urinary alkalisation for symptomatic uncomplicated urinary tract infection in women.The Cochrane database of systematic reviews · 2016Pooled it
- A pilot randomized study on use of oral acetazolamide in patients with refractory dysuria.International urology and nephrology · 2017Trial
- [Uncomplicated urinary tract infections: antibiotic-sparing approaches].Urologie (Heidelberg, Germany) · 2026Review
- Cranberry constituents prevent SOS-mediated filamentation of uropathogenicInfection and immunity · 2025Article
- Responding to Urinary Tract Infection Symptoms in England's Community Pharmacies.Antibiotics (Basel, Switzerland) · 2023Article
- A systematic review of the outcomes reported in the treatment of uncomplicated urinary tract infection clinical trials.JAC-antimicrobial resistance · 2022Review
- Non-antibiotic treatment of acute urinary tract infection in primary care: a qualitative study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Alkalising agents in urinary tract infections: theoretical contraindications, interactions and synergy.Therapeutic advances in drug safety · 2022Article
- Updates on urinary tract infections in kidney transplantation.Journal of nephrology · 2019Review
- Management of urinary tract infection in women: A practical approach for everyday practice.Urology annalsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncomplicated urinary tract infection (UTI) is the most common bacterial infection in women, characterised by dysuria and urinary frequency. Urinary alkalisers are widely used in some countries for the symptomatic treatment of uncomplicated UTI, and they are recommended in some national formularies. However, there is a lack of empirical evidence to support their use for UTI and some healthcare guidelines advise against their use.
objectivesWe aimed to look at the benefits and harms of the use of urinary alkalisers for the treatment of uncomplicated UTIs in adult women. SEARCH
methodsWe searched the Cochrane Kidney and Transplant Specialised Register to 19 January 2016 through contact with the Trials Search Co-ordinator using search terms relevant to this review. SELECTION CRITERIA: All randomised controlled trials (RCTs) and quasi-RCTs on the use of (any) urinary alkalisers (either exclusively or non-exclusively) for the symptomatic treatment of uncomplicated UTI amongst women aged 16 and over, were included. Studies were eligible if they included patients whose diagnosis of UTI was decided by symptoms alone, or positive urine dipstick test or urine culture; and patients with recurrent UTI, provided patients had no symptoms of UTI in the two weeks prior to the onset of symptoms that lead them to seek medical advice. Studies were ineligible if they studied patients with complicated UTIs; immune-compromising conditions; acute pyelonephritis; or chronic conditions such as interstitial cystitis. DATA COLLECTION AND ANALYSIS: Three authors independently assessed and screened papers, and this was repeated by two separate authors (independently). An additional investigator acted as arbitrator, where necessary. There were no papers which fulfilled the inclusion criteria for this review, and therefore no data extraction was performed. MAIN
resultsOur search identified 172 potential studies for inclusion. However, following assessment none fulfilled the inclusion criteria for this review. AUTHORS'
conclusionsUntil relevant evidence is generated from randomised trials, the safety and efficacy of urinary alkalisers for the symptomatic treatment of uncomplicated UTI remains unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.