ArticleHuman pathology2016
Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential.
Article in Human pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Imaging features of recently identified low-grade vascular neoplasia of the liver: hepatic small vessel neoplasm and anastomosing hemangioma.European radiology · 2026Article
- [Vascular neoplasms of the liver].Pathologie (Heidelberg, Germany) · 2025Article
- Non-Involuting Congenital Hepatic Hemangioma: Lessons from a Case Series.Children (Basel, Switzerland) · 2025Article
- [HSVN - hepatic small vessel neoplasm].Pathologie (Heidelberg, Germany) · 2025Article
- Mesenchymal Tumors of the Liver: An Update Review.Biomedicines · 2025Review
- GNAQ/GNA11-Related Benign and Malignant Entities-A Common Histoembriologic Origin or a Tissue-Dependent Coincidence.Cancers · 2024Review
- Vascular tumors of the liver: A brief review.Annals of hepato-biliary-pancreatic surgery · 2023Review
- Hepatic small vessel neoplasm: not totally benign, not yet malignant.Journal of pathology and translational medicine · 2023Article
- Article
- Multiple hemangiomas (hepatic small vessel neoplasia) in the liver with Budd-Chiari syndrome.Virchows Archiv : an international journal of pathology · 2023Article
- Incidental Vascular Lesion in Explanted Liver: A Rare Case Report and Review of the Literature.Case reports in hepatology · 2023Article
- Anastomosing hemangioma of the liver: An unusual variant in abdominal MRI imaging.Radiology case reports · 2022Article
- Benign liver tumours: understanding molecular physiology to adapt clinical management.Nature reviews. Gastroenterology & hepatology · 2022Review
- Multifocal hepatic small vessel neoplasm with spleen dissemination.BMJ case reports · 2022Article
- The genetics of vascular tumours: an update.Histopathology · 2022Review
- Hepatic small vessel neoplasm - A systematic review.Annals of medicine and surgery (2012) · 2021Review
- Combined Inhibition of GαClinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- [Liver sinusoids: pathology of endothelial findings].Der Pathologe · 2020Review
- Spontaneous intra-adrenal massive hematoma: possible extreme evolution of a non-secreting untreated adrenal adenoma.Journal of surgical case reports · 2020Article
- Anastomosing hemangioma of liver.Journal of radiology case reports · 2019Article
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Authors and funding
15 authors at 8 institutions in 4 countries.
Funding
Abstract
Characteristic but rare vascular neoplasms in the adult liver composed of small vessels with an infiltrative border were collected from an international group of collaborators over a 5-year period (N=17). These tumors were termed hepatic small vessel neoplasm (HSVN), and the histologic differential diagnosis was angiosarcoma (AS). The average age of patients was 54years (range, 24-83years). HSVN was more common in men. The average size was 2.1cm (range, 0.2-5.5cm). Diagnosis was aided by immunohistochemical stains for vascular lineage (CD31, CD34, FLI-1), which were uniformly positive in HSVN. Immunohistochemical stains (p53, c-Myc, GLUT-1, and Ki-67) for possible malignant potential are suggestive of a benign/low-grade tumor. Capture-based next-generation sequencing (using an assay that targets the coding regions of more than 500 cancer genes) identified an activating hotspot GNAQ mutation in 2 of 3 (67%) tested samples, and one of these cases also had a hotspot mutation in PIK3CA. When compared with hepatic AS (n=10) and cavernous hemangioma (n=6), the Ki-67 proliferative index is the most helpful tool in excluding AS, which demonstrated a tumor cell proliferative index greater than 10% in all cases. Strong p53 and diffuse c-Myc staining was also significantly associated with AS but not with HSVN or cavernous hemangioma. There have been no cases with rupture/hemorrhage, disseminated intravascular coagulation, or Kasabach-Merritt syndrome. Thus far, there has been no metastasis or recurrence of HSVN, but complete resection and close clinical follow-up are recommended because the outcome remains unknown.
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Registered trials
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