ArticleThe Journal of antimicrobial chemotherapy2016
Understanding flucloxacillin prescribing trends and treatment non-response in UK primary care: a Clinical Practice Research Datalink (CPRD) study.
Article in The Journal of antimicrobial chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.British journal of clinical pharmacology · 2018Trial
- Practice and community nurses' views and experiences of helping people manage risk factors for recurrent lower limb cellulitis: A qualitative interview study.Skin health and disease · 2024Article
- Are insect bites responsible for the rise in summer flucloxacillin prescribing in United Kingdom general practices?Family practice · 2023Article
- Presentation and management of insect bites in out-of-hours primary care: a descriptive study.BMJ open · 2023Observational
- Mapping the risk of infections in patients with multiple sclerosis: A multi-database study in the United Kingdom Clinical Practice Research Datalink GOLD and Aurum.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- HLA-associated adverse drug reactions - scoping review.Clinical and translational science · 2021Article
- Flucloxacillin-induced liver injury in elderly patient.BMJ case reports · 2021Article
- Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration.Bone & joint research · 2021Article
- Association Between Common Infections and Incident Post-Stroke Dementia: A Cohort Study Using the Clinical Practice Research Datalink.Clinical epidemiology · 2020Article
- Oral Flucloxacillin for Treating Osteomyelitis: A Narrative Review of Clinical Practice.Journal of bone and joint infection · 2020Review
- Management of cellulitis: current practice and research questions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Article
- Explaining variation in antibiotic prescribing between general practices in the UK.The Journal of antimicrobial chemotherapy · 2018Article
- Article
- Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study.The Journal of antimicrobial chemotherapy · 2017Article
- Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database.Scandinavian journal of primary health care · 2017Article
- Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study.NPJ primary care respiratory medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe volume of prescribed antibiotics is associated with antimicrobial resistance and, unlike most other antibiotic classes, flucloxacillin prescribing has increased. We aimed to describe UK primary care flucloxacillin prescribing and factors associated with subsequent antibiotic prescribing as a proxy for non-response. PATIENTS AND
methodsClinical Practice Research Datalink patients with acute prescriptions for oral flucloxacillin between January 2004 and December 2013, prescription details, associated Read codes and patient demographics were identified. Monthly prescribing rates were plotted and logistic regression identified factors associated with having a subsequent antibiotic prescription within 28 days.
results3 031 179 acute prescriptions for 1 667 431 patients were included. Average monthly prescription rates increased from 4.74 prescriptions per 1000 patient-months in 2004 to 5.74 (increase of 21.1%) in 2013. The highest prescribing rates and the largest increases in rates were seen in older adults (70+ years), but the overall increase in prescribing was not accounted for by an ageing population. Prescribing 500 mg tablets/capsules rather than 250 mg became more common. Children were frequently prescribed low doses and small volumes (5 day course) and prescribing declined for children, including for impetigo. Only 4.2% of new prescriptions involved co-prescription of another antibiotic. Age (<5 and ≥60 years), diagnosis of 'cellulitis or abscess' or no associated code, and 500 mg dose were associated with a subsequent antibiotic prescription, which occurred after 17.6% of first prescriptions.
conclusionsThere is a need to understand better the reasons for increased prescribing of flucloxacillin in primary care, optimal dosing (and the need to co-prescribe other antibiotics) and the reasons why one in five patients are prescribed a further antibiotic within 4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.