ArticleScientific reports2016
Dynamic and quantitative assessment of blood coagulation using optical coherence elastography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Optical Biosensors for Blood Coagulation Monitoring: Advantages, Limitations, and Translational Potential.Biosensors · 2026Review
- Noninvasive quantitative assessment of oral submucosal fibrosisJournal of biomedical optics · 2025Article
- Quantitative assessment of biomechanical changes in oral lesions at different cancerous stages using optical coherence elastography.Quantitative imaging in medicine and surgery · 2025Article
- Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography.Biomedical optics express · 2023Article
- Analysis of friction in quantitative micro-elastography.Biomedical optics express · 2023Article
- Measurement of Layer-Specific Mechanical Properties of Intact Blood Vessels Based on Intravascular Optical Coherence Tomography.Cardiovascular engineering and technology · 2023Article
- Article
- Characterizing blood clots using acoustic radiation force optical coherence elastography and ultrasound shear wave elastography.Physics in medicine and biology · 2021Article
- Optical coherence tomography for evaluating capillary waves in blood and plasma.Biomedical optics express · 2020Article
- Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing.Frontiers in bioengineering and biotechnology · 2019Review
- Acoustic radiation force optical coherence elastography for elasticity assessment of soft tissues.Applied spectroscopy reviews · 2019Article
- Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography.Scientific reports · 2017Article
- Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography.Applied physics letters · 2017Article
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
- 3D mapping of elastic modulus using shear wave optical micro-elastography.Scientific reports · 2016Article
- Viscosity monitoring during hemodiluted blood coagulation using optical coherence elastography.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Reliable clot diagnostic systems are needed for directing treatment in a broad spectrum of cardiovascular diseases and coagulopathy. Here, we report on non-contact measurement of elastic modulus for dynamic and quantitative assessment of whole blood coagulation using acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE). In this system, acoustic radiation force (ARF) is produced by a remote ultrasonic transducer, and a shear wave induced by ARF excitation is detected by the optical coherence tomography (OCT) system. During porcine whole blood coagulation, changes in the elastic property of the clots increase the shear modulus of the sample, altering the propagating velocity of the shear wave. Consequently, dynamic blood coagulation status can be measured quantitatively by relating the velocity of the shear wave with clinically relevant coagulation metrics, including reaction time, clot formation kinetics and maximum shear modulus. The results show that the ARFOE-OCE is sensitive to the clot formation kinetics and can differentiate the elastic properties of the recalcified porcine whole blood, blood added with kaolin as an activator, and blood spiked with fibrinogen.
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Registered trials
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