ArticleThe journal of headache and pain2016
Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Magnetoencephalography studies in migraine and headache disorders: A systematic review.Headache · 2025Pooled it
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Resting-state electroencephalography and magnetoencephalography in migraine-a systematic review and meta-analysis.The journal of headache and pain · 2024Pooled it
- Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea.Scientific reports · 2018Trial
- Vagally Mediated Heart Rate Variability and Attachment-Related Avoidance in Pediatric Migraine: A Mediated Pathway to Somatic Symptoms Severity.Children (Basel, Switzerland) · 2025Article
- Cerebral morphometric alterations predict the outcome of migraine diagnosis and subtyping: a radiomics analysis.BMC medical imaging · 2025Article
- Effects of transcranial direct current stimulation on neuro electrical activity in mice with migraine.Frontiers in neurology · 2025Article
- Altered neuromagnetic activity under visual stimuli in migraine: a multi-frequency magnetoencephalography study.Frontiers in neurology · 2025Article
- Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.The journal of headache and pain · 2024Article
- EEG Changes in Migraine-Can EEG Help to Monitor Attack Susceptibility?Brain sciences · 2024Review
- Brain connectome-based imaging markers for identifiable signature of migraine with and without aura.Quantitative imaging in medicine and surgery · 2024Article
- Impact of interictal epileptiform discharges on brain network in self-limited epilepsy with centrotemporal spikes: A magnetoencephalography study.Brain and behavior · 2023Article
- Resting State Electrophysiological Cortical Activity: A Brain Signature Candidate for Patients with Migraine.Current pain and headache reports · 2022Review
- Altered effective connectivity in migraine patients during emotional stimuli: a multi-frequency magnetoencephalography study.The journal of headache and pain · 2022Article
- Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study.Frontiers in human neuroscience · 2022Article
- Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference.Brain sciences · 2021Review
- Abnormalities in cortical pattern of coherence in migraine detected using ultra high-density EEG.Brain communications · 2021Article
- Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study.The journal of headache and pain · 2020Article
- Current understanding of cortical structure and function in migraine.Cephalalgia : an international journal of headache · 2019Review
- Migraine in childhood: an organic, biobehavioral, or psychosomatic disorder?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough alterations in resting-state neural network have been previously reported in migraine using functional MRI, whether this atypical neural network is frequency dependent remains unknown. The aim of this study was to investigate the alterations of the functional connectivity of neural network and their frequency specificity in migraineurs as compared with healthy controls by using magnetoencephalography (MEG) and concepts from graph theory.
methodsTwenty-three episodic migraine patients with and without aura, during the interictal period, and 23 age- and gender-matched healthy controls at resting state with eye-closed were studied with MEG. Functional connectivity of neural network from low (0.1-1 Hz) to high (80-250 Hz) frequency ranges was analyzed with topographic patterns and quantified with graph theory.
resultsThe topographic patterns of neural network showed that the migraineurs had significantly increased functional connectivity in the slow wave (0.1-1 Hz) band in the frontal area as compared with controls. Compared with the migraineurs without aura (MwoA), the migraineurs with aura (MwA) had significantly increased functional connectivity in the theta (4-8 Hz) band in the occipital area. Graph theory analysis revealed that the migraineurs had significantly increased connection strength in the slow wave (0.1-1 Hz) band, increased path length in the theta (4-8 Hz) and ripple (80-250 Hz) bands, and increased clustering coefficient in the slow wave (0.1-1 Hz) and theta (4-8 Hz) bands. The clinical characteristics had no significant correlation with interictal MEG parameters.
conclusionsResults indicate that functional connectivity of neural network in migraine is significantly impaired in both low- and high-frequency ranges. The alteration of neural network may imply that migraine is associated with functional brain reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.