Evidence map›Paper›PMID 27090417›Full record

ArticleThe journal of headache and pain2016

Progressive muscle relaxation reduces migraine frequency and normalizes amplitudes of contingent negative variation (CNV).

Bianca Meyer, Armin Keller, Hans-Georg Wöhlbier, Claudia Helene Overath, Britta Müller, Peter Kropp

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Guideline
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  4. Psychological therapies for the prevention of migraine in adults.The Cochrane database of systematic reviews · 2019
    Pooled it
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  8. Psychological interventions for migraine.Nature reviews. Neurology · 2026
    Review
  9. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bianca MeyerInstitute of Medical Psychology and Medical Sociology, University Medicine Rostock, Gehlsheimer Straße 20, 18246, Rostock, Germany. bianca.meyer@med.uni-rostock.de.
Armin KellerInstitute of Medical Psychology and Medical Sociology, University Medicine Rostock, Gehlsheimer Straße 20, 18246, Rostock, Germany.
Hans-Georg WöhlbierInstitute of Medical Psychology and Medical Sociology, University Medicine Rostock, Gehlsheimer Straße 20, 18246, Rostock, Germany.
Claudia Helene OverathCenter of Integrative Psychiatry, University Clinic of Schleswig-Holstein, Niemannsweg 147, Haus 1, 24105, Kiel, Germany.
Britta MüllerInstitute of Medical Psychology and Medical Sociology, University Medicine Rostock, Gehlsheimer Straße 20, 18246, Rostock, Germany.
Peter KroppInstitute of Medical Psychology and Medical Sociology, University Medicine Rostock, Gehlsheimer Straße 20, 18246, Rostock, Germany.
University Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral information processing, visible in evoked potentials like the contingent negative variation (CNV) is altered in migraine patients who exhibit higher CNV amplitudes and a reduced habituation. Both characteristics were shown to be normalized under different prophylactic migraine treatment options whereas Progressive Muscle Relaxation (PMR) has not yet been examined. We investigated the effect of PMR on clinical course and CNV in migraineurs in a quasi-randomized, controlled trial.

methodsThirty-five migraine patients and 46 healthy controls were examined. Sixteen migraineurs and 21 healthy participants conducted a 6-week PMR-training with CNV-measures before and after as well as three months after PMR-training completion. The remaining participants served as controls. The clinical course was analyzed with two-way analyses of variance (ANOVA) with repeated measures. Pre-treatment CNV differences between migraine patients and healthy controls were examined with t-tests for independent measures. The course of the CNV-parameters was examined with three-way ANOVAs with repeated measures.

resultsAfter PMR-training, migraine patients showed a significant reduction of migraine frequency. Preliminary to the PMR-training, migraine patients exhibited higher amplitudes in the early component of the CNV (iCNV) and the overall CNV (oCNV) than healthy controls, but no differences regarding habituation. After completion of the PMR-training, migraineurs showed a normalization of the iCNV amplitude, but neither of the oCNV nor of the habituation coefficient.

conclusionsThe results confirm clinical efficacy of PMR for migraine prophylaxis. The pre-treatment measure confirms altered cortical information processing in migraine patients. Regarding the changes in the iCNV after PMR-training, central nervous mechanisms of the PMR-effect are supposed which may be mediated by the serotonin metabolism.

Indexed as

AdultAutogenic TrainingBrainContingent Negative VariationFemaleHumansMaleMigraine DisordersTreatment OutcomeContingent negative variationCortical preactivationMigraineMigraine prophylaxisProgressive muscle relaxation

Identifiers

PMID27090417
PMCPMC4835398
OpenAlexW2339146840

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.