Evidence map›Paper›PMID 27090305›Full record

ReviewMolecular psychiatry2016

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways.

G B Rogers, D J Keating, R L Young, M-L Wong, J Licinio, S Wesselingh

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 508 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
508citing papers in PubMed, 10 pooled it
40.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04179006 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2019 to 2023Enrolled120ConditionsDepressive Disorder, MajorArmsLF/Erinacine A-enriched Hericium/Plain chocolate + antidepressant(s)
NCT05688618 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of the Administration of a Symbiotic (E. Faecium and Agave Inulin) on Mild Cognitive Impairment in Older Adults

TypeinterventionalSponsorAnahuac UniversityRan2022 to 2024Enrolled48ConditionsCognitive ImpairmentArmsEnteroccocus Facieum and Agave Inulin, Placebo
3 · Its place in the literature

Who cites it

508 citing papers in PubMed, 10 syntheses or guidelines pooled it, 936 citations in OpenAlex.

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  6. The effects ofFrontiers in nutrition · 2025
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448 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

G B RogersSouth Australian Health and Medical Research Institute, Infection and Immunity Theme, School of Medicine, Flinders University, Adelaide, SA, Australia.
D J KeatingSouth Australian Health and Medical Research Institute, Centre for Neuroscience and Department of Human Physiology, Flinders University, Adelaide, SA, Australia.
R L YoungSouth Australian Health and Medical Research Institute, Department of Medicine, University of Adelaide, Adelaide, SA, Australia.
M-L WongSouth Australian Health and Medical Research Institute, Mind and Brain Theme, and Flinders University, Adelaide, SA, Australia.
J LicinioSouth Australian Health and Medical Research Institute, Mind and Brain Theme, and Flinders University, Adelaide, SA, Australia.
S WesselinghSouth Australian Health and Medical Research Institute, Infection and Immunity Theme, School of Medicine, Flinders University, Adelaide, SA, Australia.
Flinders University · AUSouth Australian Health and Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a growing number of diseases. Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition and behaviour, with recent evidence that changes in behaviour alter gut microbiota composition, while modifications of the microbiome can induce depressive-like behaviours. Although an association between enteropathy and certain psychiatric conditions has long been recognized, it now appears that gut microbes represent direct mediators of psychopathology. Here, we examine roles of gut microbiome in shaping brain development and neurological function, and the mechanisms by which it can contribute to mental illness. Further, we discuss how the insight provided by this new and exciting field of research can inform care and provide a basis for the design of novel, microbiota-targeted, therapies.

Indexed as

AnimalsBrainCentral Nervous SystemCognitionDysbiosisGastrointestinal MicrobiomeGastrointestinal TractHumansMental DisordersMicrobiota

Identifiers

PMID27090305
PMCPMC4879184
OpenAlexW2340717842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.