ArticleEuropean radiology2016
Simultaneous trans-hepatic portal and hepatic vein embolization before major hepatectomy: the liver venous deprivation technique.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04692259 (Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection), which is not on this map. Cited by 113 papers, 9 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection
Who cites it
113 citing papers in PubMed, 9 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Meta-analysis of liver venous deprivation vs portal vein embolization in treating liver cancer with an insufficient liver remnant.Journal of the Chinese Medical Association : JCMA · 2025Pooled it
- CIRSE Standards of Practice on Portal Vein Embolization and Double Vein Embolization/Liver Venous Deprivation.Cardiovascular and interventional radiology · 2024Guideline
- A systematic review and meta-analysis of liver venous deprivation versus portal vein embolization before hepatectomy: future liver volume, postoperative outcomes, and oncological safety.Frontiers in medicine · 2023Pooled it
- Efficacy and safety of different options for liver regeneration of future liver remnant in patients with liver malignancies: a systematic review and network meta-analysis.World journal of surgical oncology · 2022Pooled it
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- Impact of sarcopenia on the future liver remnant growth after portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy in patients with liver cancer: A systematic review.Frontiers in oncology · 2022Pooled it
- Predictive Factors for Hypertrophy of the Future Liver Remnant After Portal Vein Embolization: A Systematic Review.Cardiovascular and interventional radiology · 2021Pooled it
- Portal vein embolization with N-butyl cyanoacrylate glue is superior to other materials: a systematic review and meta-analysis.European radiology · 2021Pooled it
- The emerging role of 4D flow MRI in abdominal interventional radiology.Abdominal radiology (New York) · 2026Review
- CT Radiomics to Predict Regenerative Biomarker Expression after Liver Venous Embolization: Proof-of-Concept in a Porcine Model.Journal of vascular and interventional radiology : JVIR · 2026Article
- When is enough enough?-predicting adequacy of portal vein embolization for hypertrophy of the future liver remnant in the age of liver venous deprivation.Hepatobiliary surgery and nutrition · 2026Article
- Article
- Does a patient who needs portal vein embolization (PVE) to proceed to major hepatectomy (MH) have the same hepatic functional reserve than a patient with no preoperative PVE?Hepatobiliary surgery and nutrition · 2026Article
- Liver venous deprivation before major hepatectomy-promising but still a work in progress.Hepatobiliary surgery and nutrition · 2026Article
- [Conditioning and systemic treatment before extensive liver resection].Chirurgie (Heidelberg, Germany) · 2026Review
- Hepatic Hypertrophy Techniques: Comparing Perioperative Outcomes of Liver Venous Deprivation (LVD) and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy-Variants (vALPPS) Among Two Referral Centers.Annals of surgical oncology · 2026Article
- ASO Author Reflections: From Competition to Coexistence: Revisiting ALPPS and Liver Venous Deprivation.Annals of surgical oncology · 2026Article
- Efficacy of Sequential Hepatic Vein Embolization Following Portal Vein Embolization in Promoting Regeneration of Liver Volume and Function Before Right-Sided Major Hepatectomy.Annals of gastroenterological surgery · 2026Article
- Should all patients be offered liver venous deprivation for insufficient future liver remnant hypertrophy prior to major hepatectomy?Hepatobiliary surgery and nutrition · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess technical feasibility, safety, and efficacy of the liver venous deprivation (LVD) technique that combines both portal and hepatic vein embolization during the same procedure for liver preparation before major hepatectomy. MATERIALS AND
methodsSeven patients (mean age:63.6y[42-77y]) underwent trans-hepatic LVD for liver metastases (n = 2), hepatocellular carcinoma (n = 1), intrahepatic cholangiocarcinoma (n = 3) and Klatskin tumour (n = 1). Assessment of future remnant liver (FRL) volume, liver enzymes and histology was performed.
resultsTechnical success was 100 %. No complication occurred before surgery. Resection was performed in 6/7 patients. CT-scan revealed hepatic congestion in the venous-deprived area (6/7 patients). A mean of 3 days (range: 1-8 days) after LVD, transaminases increased (AST: from 42 ± 24U/L to 103 ± 118U/L, ALT: from 45 ± 25U/L to 163 ± 205U/L). Twenty-three days (range: 13-30 days) after LVD, FRL increased from 28.2 % (range: 22.4-33.3 %) to 40.9 % (range: 33.6-59.3 %). During the first 7 days, venous-deprived liver volume increased (+13.4 %) probably reflecting vascular congestion, whereas it strongly decreased (-21.3 %) at 3-4 weeks. Histology (embolized lobe) revealed sinusoidal dilatation, hepatocyte necrosis and important atrophy in all patients.
conclusionTrans-hepatic LVD technique is feasible, well tolerated and provides fast and important hypertrophy of the FRL. This new technique needs to be further evaluated and compared to portal vein embolization. KEY POINTS: • Twenty-three days after LVD, FRL increased from 28.2 % (range:22.4-33.3 %) to 40.9 % (range:33.6-59.3 %) • During the first 7 days, venous-deprived liver volume increased (+13.4 %) • Venous-deprived liver volume strongly decreased (mean atrophy:229 cc; -21.3 %) at 3-4 weeks • Histology of venous-deprived liver revealed sinusoidal dilatation, hepatocyte necrosis and important atrophy.
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