ArticleInternational journal of obesity (2005)2016
Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans.International journal of obesity (2005) · 2017Trial
- Frequency-domain broadband near-infrared spectroscopy for noninvasive monitoring of fluid volume status during hemodialysis.Biophotonics discovery · 2026Article
- MR-based fat fraction changes in subcutaneous adipose tissue in people with obesity undergoing a weight loss intervention: results from the LION study.Quantitative imaging in medicine and surgery · 2025Article
- Frequency domain broadband short-wave infrared spectroscopy for measurement of tissue optical properties from 685 to 1300 nm.Journal of biomedical optics · 2025Article
- Finite Element Modeling of Abdominal Near-Infrared Spectroscopy for Infant Splanchnic Oximetry.International journal for numerical methods in biomedical engineering · 2025Article
- Development of a sex-specific visceral fat area estimation using discrete multi-wavelength near-infrared spectroscopy measurements in Korean individuals.International journal of obesity (2005) · 2025Article
- Non-invasive optical and laboratory hematologic biomarkers correlate in patients with sickle cell disease.Biomedical optics express · 2024Article
- Hybrid Bladder Phantom to Validate Next-Generation Optical Wearables for Neurogenic Bladder Volume Monitoring.International neurourology journal · 2023Article
- Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited].Biomedical optics express · 2023Review
- Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.Theranostics · 2023Article
- Smartphone-based single snapshot spatial frequency domain imaging.Biomedical optics express · 2022Article
- Diffuse optical spectroscopic method for tissue and body composition assessment.Journal of biomedical optics · 2022Article
- A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging.Biomedical optics express · 2021Article
- Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics.Journal of biomedical optics · 2021Article
- Narrowband diffuse reflectance spectroscopy in the 900-1000 nm wavelength region to quantify water and lipid content of turbid media.Biomedical optics express · 2021Article
- Dual-Slope Diffuse Reflectance Instrument for Calibration-Free Broadband Spectroscopy.Applied sciences (Basel, Switzerland) · 2021Article
- Quantitative diffuse optical spectroscopy for noninvasive measurements of the malaria pigment hemozoin.Biomedical optics express · 2020Article
- Non-invasive investigation of adipose tissue by time domain diffuse optical spectroscopy.Biomedical optics express · 2020Article
- The role of adipose tissue in cardiovascular health and disease.Nature reviews. Cardiology · 2019 · on this mapReview
- Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine.Military medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChanges in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity and related metabolic disorders. Measurements of AT physiology could provide new insight into metabolic disease progression and response to therapy. An emerging functional imaging technology, diffuse optical spectroscopic imaging (DOSI), was used to obtain quantitative measures of near infrared (NIR) AT optical and physiological properties.
methodsTen overweight or obese adults were assessed during 3 months on calorie-restricted diets. DOSI-derived tissue concentrations of hemoglobin, water and lipid and the wavelength-dependent scattering amplitude (A) and slope (b) obtained from 30 abdominal locations and three time points (T0, T6, T12) were calculated and analyzed using linear mixed-effects models and were also used to form 3D surface images.
resultsSubjects lost a mean of 11.7±3.4% of starting weight, while significant changes in A (+0.23±0.04 mm(-1), adj. P<0.001),b (-0.17±0.04, adj. P<0.001), tissue water fraction (+7.2±1.1%, adj. P<0.001) and deoxyhemoglobin (1.1±0.3 μM, adj. P<0.001) were observed using mixed-effect model analysis. DISCUSSION: Optical scattering signals reveal alterations in tissue structure that possibly correlate with reductions in adipose cell volume, while water and hemoglobin dynamics suggest improved AT perfusion and oxygen extraction. These results suggest that DOSI measurements of NIR optical and physiological properties could be used to enhance understanding of the role of AT in metabolic disorders and provide new strategies for diagnostic monitoring of obesity and weight loss.
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