Evidence map›Paper›PMID 27089938›Full record

ArticleThe pharmacogenomics journal2017

Genetic variation in the alpha

A Adefurin, L V Ghimire, U Kohli, M Muszkat, G G Sofowora, C Li, R T Levinson, S Y Paranjape, C M Stein, D Kurnik

Registry-linked trialAbstract read
In one paragraph

Article in The pharmacogenomics journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00838695 (Variability in Adrenergic Response), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00838695 nacompletednot on this map

Variability in Adrenergic Response

TypeinterventionalSponsorVanderbilt UniversityRan2009 to 2011Enrolled106ConditionsVascular Reaction to MedicationsArmsPhenylephrine
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Preliminary antifibrotic and vasoconstrictor effects of adrenaline in Schlemm's canal and suprachoroidal minimally invasive glaucoma surgery in primary open-angle glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Race and sex differences in cardiovascular autonomic regulation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

A AdefurinDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
L V GhimireDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
U KohliDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
M MuszkatDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
G G SofoworaDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
C LiDepartment of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
R T LevinsonVanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.
S Y ParanjapeDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
C M SteinDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
D KurnikDivision of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Vanderbilt University · USTechnion – Israel Institute of Technology · IL

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4M
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS P01 HL056693NIGMS NIH HHS T32 GM007569
6 · The paper itself

Abstract

The alpha

Indexed as

AdultBlack or African AmericanBlack PeopleCatecholaminesFemaleGenetic VariationGenotypeHumansMalePhenylephrineReceptors, Adrenergic, alpha-1VasoconstrictionVeinsWhite PeopleADRA1B protein, humanCatecholaminesPhenylephrineReceptors, Adrenergic, alpha-1

Identifiers

PMID27089938
PMCPMC5071105
OpenAlexW2336333999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.