ArticleScientific reports2016
Leveraging family-specific signatures for AMP discovery and high-throughput annotation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Isolation and Characterization of St-CRPs: Cysteine-Rich Peptides from the Arctic Marine AscidianMarine drugs · 2026Article
- Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides.Protein science : a publication of the Protein Society · 2025Article
- Quantum Annealing Designs Nonhemolytic Antimicrobial Peptides in a Discrete Latent Space.ACS medicinal chemistry letters · 2023Article
- CAMPR4: a database of natural and synthetic antimicrobial peptides.Nucleic acids research · 2023Article
- Too Hot to Handle: Antibacterial Peptides Identified in Ghost Pepper.Journal of natural products · 2021Article
- New Insect Host Defense Peptides (HDP) From Dung Beetle (Coleoptera: Scarabaeidae) Transcriptomes.Journal of insect science (Online) · 2021Article
- Anaerobic gut fungi are an untapped reservoir of natural products.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial AscidianMarine drugs · 2020Article
- Collection of antimicrobial peptides database and its derivatives: Applications and beyond.Protein science : a publication of the Protein Society · 2020Article
- DRAMP 2.0, an updated data repository of antimicrobial peptides.Scientific data · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) are diverse, biologically active, essential components of the innate immune system. As compared to conventional antibiotics, AMPs exhibit broad spectrum antimicrobial activity, reduced toxicity and reduced microbial resistance. They are widely researched for their therapeutic potential, especially against multi-drug resistant pathogens. AMPs are known to have family-specific sequence composition, which can be mined for their discovery and rational design. Here, we present a detailed family-based study on AMP families. The study involved the use of sequence signatures represented by patterns and hidden Markov models (HMMs) present in experimentally studied AMPs to identify novel AMPs. Along with AMPs, peptides hitherto lacking antimicrobial annotation were also retrieved and wet-lab studies on randomly selected sequences proved their antimicrobial activity against Escherichia coli. CAMPSign, a webserver has been created for researchers to effortlessly exploit the use of AMP family signatures for identification of AMPs. The webserver is available online at www.campsign.bicnirrh.res.in. In this work, we demonstrate an optimised and experimentally validated protocol along with a freely available webserver that uses family-based sequence signatures for accelerated discovery of novel AMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.