ArticlePloS one2016
Parasympathetic Nervous System Dysfunction, as Identified by Pupil Light Reflex, and Its Possible Connection to Hearing Impairment.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
- Exploring the relative stability of automated infrared pupillometry parameters under sedative and analgesic exposure after cardiac surgery.BMC anesthesiology · 2026Observational
- Characterizing Initial Cervical Spine and Neurovascular Findings in 84 Consecutive Patients with Hypermobile Ehlers-Danlos Syndrome: A Retrospective Study.Journal of clinical medicine · 2026Article
- Acute Mental Stress is Associated With Altered Pupillary Light Reflex.Physiological research · 2025Article
- The genetic landscape of pediatric postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Objective test findings in patients with chronic eye symptoms seeking care at an outpatient neck center: ligamentous cervical instability etiology?Frontiers in neurology · 2025Article
- Spatial separation enhances speech intelligibility but increases listening effort with session-dependent variability in pupillometric measures.Frontiers in neuroscience · 2025Article
- Measuring the Pupillary Light Reflex Using Portable Instruments in Applied Settings.Vision (Basel, Switzerland) · 2024Article
- Characterising cerebrovascular reactivity and the pupillary light response-a comparative study.Frontiers in physiology · 2024Article
- PupillOmetry for preDIction of DeliriUM in ICU (PODIUM): protocol for a prospective multicentre cohort study.BMJ open · 2023Article
- Autonomic Nervous System and Control of Visual Function.Annals of neurosciences · 2023Article
- Association of nocturnal sleep duration and midday napping with subjective poor hearing among middle-aged and older adults in China.Frontiers in public health · 2023Article
- Impact of SNR, peripheral auditory sensitivity, and central cognitive profile on the psychometric relation between pupillary response and speech performance in CI users.Frontiers in neuroscience · 2023Article
- Pupil light reflex dynamics in Parkinson's disease.Frontiers in integrative neuroscience · 2023Article
- The impact of Alzheimer's disease risk factors on the pupillary light response.Frontiers in neuroscience · 2023Review
- Cervical muscle stiffness and parasympathetic nervous system improvements for treatment-resistant depression.BMC musculoskeletal disorders · 2022Observational
- Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.Journal of neurology · 2022Article
- Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions.Vision (Basel, Switzerland) · 2022Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAlthough the pupil light reflex has been widely used as a clinical diagnostic tool for autonomic nervous system dysfunction, there is no systematic review available to summarize the evidence that the pupil light reflex is a sensitive method to detect parasympathetic dysfunction. Meanwhile, the relationship between parasympathetic functioning and hearing impairment is relatively unknown.
objectivesTo 1) review the evidence for the pupil light reflex being a sensitive method to evaluate parasympathetic dysfunction, 2) review the evidence relating hearing impairment and parasympathetic activity and 3) seek evidence of possible connections between hearing impairment and the pupil light reflex.
methodsLiterature searches were performed in five electronic databases. All selected articles were categorized into three sections: pupil light reflex and parasympathetic dysfunction, hearing impairment and parasympathetic activity, pupil light reflex and hearing impairment.
resultsThirty-eight articles were included in this review. Among them, 36 articles addressed the pupil light reflex and parasympathetic dysfunction. We summarized the information in these data according to different types of parasympathetic-related diseases. Most of the studies showed a difference on at least one pupil light reflex parameter between patients and healthy controls. Two articles discussed the relationship between hearing impairment and parasympathetic activity. Both studies reported a reduced parasympathetic activity in the hearing impaired groups. The searches identified no results for pupil light reflex and hearing impairment. DISCUSSION AND
conclusionsAs the first systematic review of the evidence, our findings suggest that the pupil light reflex is a sensitive tool to assess the presence of parasympathetic dysfunction. Maximum constriction velocity and relative constriction amplitude appear to be the most sensitive parameters. There are only two studies investigating the relationship between parasympathetic activity and hearing impairment, hence further research is needed. The pupil light reflex could be a candidate measurement tool to achieve this goal.
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