Evidence map›Paper›PMID 27089377›Full record

ReviewBiosensors2016

Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms.

Piyush Dak, Aida Ebrahimi, Vikhram Swaminathan, Carlos Duarte-Guevara, Rashid Bashir, Muhammad A Alam

Abstract readReview
In one paragraph

Review in Biosensors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Piyush DakPurdue University, West Lafayette 47906, IN, USA. pdak@purdue.edu.
Aida EbrahimiPurdue University, West Lafayette 47906, IN, USA. sebrahim@purdue.edu.
Vikhram SwaminathanUniversity of Illinois at Urbana-Champaign, Urbana 61801, IL, USA. vikhram2@illinois.edu.
Carlos Duarte-GuevaraUniversity of Illinois at Urbana-Champaign, Urbana 61801, IL, USA. duarteg2@illinois.edu.
Rashid BashirUniversity of Illinois at Urbana-Champaign, Urbana 61801, IL, USA. rbashir@illinois.edu.
Muhammad A AlamPurdue University, West Lafayette 47906, IN, USA. alam@purdue.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low cost, portable sensors can transform health care by bringing easily available diagnostic devices to low and middle income population, particularly in developing countries. Sample preparation, analyte handling and labeling are primary cost concerns for traditional lab-based diagnostic systems. Lab-on-a-chip (LoC) platforms based on droplet-based microfluidics promise to integrate and automate these complex and expensive laboratory procedures onto a single chip; the cost will be further reduced if label-free biosensors could be integrated onto the LoC platforms. Here, we review some recent developments of label-free, droplet-based biosensors, compatible with "open" digital microfluidic systems. These low-cost droplet-based biosensors overcome some of the fundamental limitations of the classical sensors, enabling timely diagnosis. We identify the key challenges that must be addressed to make these sensors commercially viable and summarize a number of promising research directions.

Indexed as

Biosensing TechniquesLab-On-A-Chip DevicesMicrofluidicsDiffusionHumansNucleic Acid HybridizationPoint-of-Care SystemsSensitivity and Specificitybiosensorsdropletearly detectionhigh sensitivitylab-on-a-chippoint-of-care

Identifiers

PMID27089377
PMCPMC4931474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.