Evidence map›Paper›PMID 27089332›Full record

ArticleInternational journal of molecular sciences2016

MiRTargetLink--miRNAs, Genes and Interaction Networks.

Maarten Hamberg, Christina Backes, Tobias Fehlmann, Martin Hart, Benjamin Meder, Eckart Meese, Andreas Keller

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Trial
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  4. Construction and Analysis of miRNA Regulatory Networks.Methods in molecular biology (Clifton, N.J.) · 2026
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maarten HambergChair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. e.j.m.hamberg@gmail.com.
Christina BackesChair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. c.backes@mx.uni-saarland.de.
Tobias FehlmannChair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. tobias.fehlmann@ccb.uni-saarland.de.
Martin HartDepartment of Human Genetics, Saarland University, Homburg D-66421, Germany. marhar15@googlemail.com.
Benjamin MederInternal Medicine, Heidelberg University, Heidelberg D-69120, Germany. benjamin.meder@med.uni-heidelberg.de.
Eckart MeeseDepartment of Human Genetics, Saarland University, Homburg D-66421, Germany. hgemee@uks.eu.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. andreas.keller@ccb.uni-saarland.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool for automating respective analysis procedures that are frequently applied. Input of the web-based solution is either a single gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated and predicted targets are extracted from databases and an interaction network is presented. Users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered. Central genes or miRNAs are highlighted and users can navigate through the network interactively. To discover the most relevant biochemical processes influenced by the target network, gene set analysis and miRNA set analysis are integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac miRNAs. miRTargetLink is freely available without restrictions at www.ccb.uni-saarland.de/mirtargetlink.

Indexed as

Gene Regulatory NetworksSoftwareDatabases, GeneticHumansInternetMicroRNAsMicroRNAsgenesinteraction networksmiRNAsmiRTargetkLink

Identifiers

PMID27089332
PMCPMC4849020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.