ArticleInternational journal of molecular sciences2016
The Molecular Epidemiology and Evolutionary Dynamics of Influenza B Virus in Two Italian Regions during 2010-2015: The Experience of Sicily and Liguria.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Antigenic analysis of the influenza B virus hemagglutinin protein.Virologica Sinica · 2025Article
- Genetic characterisation of the influenza viruses circulating in Bulgaria during the 2019-2020 winter season.Virus genes · 2021Article
- Epidemiological and evolutionary dynamics of influenza B virus in coastal Kenya as revealed by genomic analysis of strains sampled over a single season.Virus evolution · 2020Article
- Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012-2019.Microorganisms · 2020Article
- Surveillance Data for Eight Consecutive Influenza Seasons in Sicily, Italy.The American journal of tropical medicine and hygiene · 2019Article
- Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004-2017.BMC infectious diseases · 2019Article
- Virological Surveillance of Influenza in the eight epidemic seasons after the 2009 pandemic in Emilia-Romagna (Northern Italy).Acta bio-medica : Atenei Parmensis · 2019Article
- Molecular evolution of influenza B virus during 2011-2017 in Chaoyang, Beijing, suggesting the free influenza vaccine policy.Scientific reports · 2019Article
- Predominance of influenza B/Yamagata lineage viruses in Bulgaria during the 2017/2018 season.Epidemiology and infection · 2019Article
- Influenza B viruses in pigs, Taiwan.Influenza and other respiratory viruses · 2019Article
- Trends of influenza B during the 2010-2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisation strategy.Human vaccines & immunotherapeutics · 2018Article
- Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal.International journal of microbiology · 2018Article
- Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2017Article
- Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: A focus on type B virus and the effects of vaccine mismatch in Liguria region, Italy.Human vaccines & immunotherapeutics · 2017Article
- Infectious Diseases: Pathophysiology, Diagnostics and Prevention.International journal of molecular sciences · 2016Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Molecular epidemiology of influenza B virus remained poorly studied in Italy, despite representing a major contributor to seasonal epidemics. This study aimed to reconstruct the phylogenetic relationships and genetic diversity of the hemagglutinin gene sequences of 197 influenza B strains circulating in both Southern (Sicily) and Northern (Liguria) Italy between 2010 and 2015. Upper respiratory tract specimens of patients displaying symptoms of influenza-like illness were screened by real-time RT-PCR assay for the presence of influenza B virus. PCR-positive influenza B samples were further analyzed by sequencing. Neighbor-joining phylogenetic trees were constructed and the amino-acid alignments were analyzed. Phylogenetic analysis showed clusters in B/Victoria clade 1A/1B (n = 29, 14.7%), and B/Yamagata clades 2 (n = 112, 56.8%) and 3 (n = 56, 28.4%). Both influenza B lineages were found to co-circulate during the study period, although a lineage swap from B/Victoria to B/Yamagata occurred in Italy between January 2011 and January 2013. The most represented amino-acid substitutions were N116K in the 120-loop (83.9% of B/Yamagata clade 3 strains) and I146V in the 150-loop (89.6% of B/Victoria clade 1 strains). D197N in 190-helix was found in almost all viruses collected. Our findings provide further evidence to support the adoption of quadrivalent influenza vaccines in our country.
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