ArticleACS nano2016
Ion-Switchable Quantum Dot Förster Resonance Energy Transfer Rates in Ratiometric Potassium Sensors.
Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Polydopamine based ion-selective nanosensor for electrolyte sensing.Mikrochimica acta · 2026Article
- Coupling Organic Ultralong Lifetime Phosphorescence Materials with Paper-Based Bioanalytical Architectures for Autofluorescence-Free Sensing.ACS sensors · 2025Article
- The impact of zwitterionic surfactants on optode-based nanosensorsThe Analyst · 2024Article
- Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications.Nanoscale advances · 2023Review
- Surface PEGylation of ionophore-based microspheres enables determination of serum sodium and potassium ion concentration under flow cytometry.Analytical and bioanalytical chemistry · 2023Article
- Perspective on fluorescence cell imaging with ionophore-based ion-selective nano-optodes.Biomicrofluidics · 2022Article
- A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells.Chemical science · 2020Article
- A highly sensitive and selective nanosensor for near-infrared potassium imaging.Science advances · 2020Article
- Fluorometric immunoassay for the simultaneous determination of the tumor markers carcinoembryonic antigen and cytokeratin 19 fragment using two kinds of CdSe/ZnS quantum dot nanobeads and magnetic beads.Mikrochimica acta · 2020Article
- Luminescent Nanosensors for Ratiometric Monitoring of Three-Dimensional Oxygen Gradients in Laboratory and Clinical Pseudomonas aeruginosa Biofilms.Applied and environmental microbiology · 2019Article
- Article
- Recent Developments in Nanosensors for Imaging Applications in Biological Systems.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging.ACS nano · 2018Article
- Optical Probes for Neurobiological Sensing and Imaging.Accounts of chemical research · 2018Review
- Ratiometric optical nanoprobes enable accurate molecular detection and imaging.Chemical Society reviews · 2018Review
- A method for estimating intracellular ion concentration using optical nanosensors and ratiometric imaging.Scientific reports · 2017Article
- Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium.Analytical chemistry · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The tools for optically imaging cellular potassium concentrations in real-time are currently limited to a small set of molecular indicator dyes. Quantum dot-based nanosensors are more photostable and tunable than organic indicators, but previous designs have fallen short in size, sensitivity, and selectivity. Here, we introduce a small, sensitive, and selective nanosensor for potassium measurements. A dynamic quencher modulates the fluorescence emitted by two different quantum dot species to produce a ratiometric signal. We characterized the potassium-modulated sensor properties and investigated the photonic interactions within the sensors. The quencher's protonation changes in response to potassium, which modulates its Förster radiative energy transfer rate and the corresponding interaction radii with each quantum dot species. The nanosensors respond to changes in potassium concentrations typical of the cellular environment and thus provide a promising tool for imaging potassium fluxes during biological events.
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Registered trials
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