ArticleNature neuroscience2016
Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Enhanced multisensory integration in the olfactory bulb of the Mexican cavefish.bioRxiv : the preprint server for biology · 2026Article
- Connectomes: a re-emerging hub dataset for neuroscience.Frontiers in neuroscience · 2026Review
- An essential experimental control for functional connectivity mapping with optogenetics.Genetics · 2025Article
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- The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision.Neuron · 2024Article
- Functional connectomics reveals general wiring rule in mouse visual cortex.bioRxiv : the preprint server for biology · 2024Article
- Fast imaging of millimeter-scale areas with beam deflection transmission electron microscopy.Nature communications · 2024Article
- Quantitative evaluation of embedding resins for volume electron microscopy.Frontiers in neuroscience · 2024Article
- Studying zebrafish nervous system structure and function in health and disease with electron microscopy.Development, growth & differentiation · 2023Review
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Minimal resin embedding of SBF-SEM samples reduces charging and facilitates finding a surface-linked region of interest.Frontiers in zoology · 2023Article
- Dense 4D nanoscale reconstruction of living brain tissue.Nature methods · 2023Article
- Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts.Cancer research communications · 2023Article
- Seg2Link: an efficient and versatile solution for semi-automatic cell segmentation in 3D image stacks.Scientific reports · 2023Article
- Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain.Nature methods · 2022Article
- Mapping of the zebrafish brain takes shape.Nature methods · 2022Article
- Article
- Whole-cell observation of ZIO-stained Golgi apparatus in rat hepatocytes with serial block-face scanning electron microscope, SBF-SEM.Microscopy (Oxford, England) · 2022Article
- How innovations in methodology offer new prospects for volume electron microscopy.Journal of microscopy · 2022Review
1 more citing papers are in PubMed but not listed here.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The dense reconstruction of neuronal circuits from volumetric electron microscopy (EM) data has the potential to uncover fundamental structure-function relationships in the brain. To address bottlenecks in the workflow of this emerging methodology, we developed a procedure for conductive sample embedding and a pipeline for neuron reconstruction. We reconstructed ∼98% of all neurons (>1,000) in the olfactory bulb of a zebrafish larva with high accuracy and annotated all synapses on subsets of neurons representing different types. The organization of the larval olfactory bulb showed marked differences from that of the adult but similarities to that of the insect antennal lobe. Interneurons comprised multiple types but granule cells were rare. Interglomerular projections of interneurons were complex and bidirectional. Projections were not random but biased toward glomerular groups receiving input from common types of sensory neurons. Hence, the interneuron network in the olfactory bulb exhibits a specific topological organization that is governed by glomerular identity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.