ArticleAmerican journal of respiratory and critical care medicine2016
Daily Home Spirometry: An Effective Tool for Detecting Progression in Idiopathic Pulmonary Fibrosis.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07673237 (Remote Evaluation and Surveillance of Patients With Interstitial Lung Disease), which is not on this map. Cited by 100 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Remote Evaluation and Surveillance of Patients With Interstitial Lung Disease: Transforming ILD Care Delivery With Remote Monitoring
Who cites it
100 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Unsupervised home spirometryEuropean respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Prognosis of idiopathic pulmonary fibrosis without anti-fibrotic therapy: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2020Pooled it
- Home spirometry in patients with idiopathic pulmonary fibrosis: data from the INMARK trial.The European respiratory journal · 2021Trial
- A phase IIb, randomised, parallel-group study: the efficacy, safety and tolerability of once-daily umeclidinium in patients with asthma receiving inhaled corticosteroids.Respiratory research · 2020Trial
- Modelling Forced Vital Capacity in Idiopathic Pulmonary Fibrosis: Optimising Trial Design.Advances in therapy · 2019Trial
- Automated quantitative analysis can support the identification of progressive pulmonary fibrosis in fibrotic interstitial lung disease.BMJ open respiratory research · 2026Article
- Expanding Remote Patient Monitoring for Pre-Lung Transplant Candidates With Interstitial Lung Disease.Clinical transplantation · 2026Article
- Design of a randomized controlled trial comparing hybrid care with standard care for people with pulmonary fibrosis.Respiratory research · 2026Article
- Prospective study of fibrosis in the lung endpoints (PROFILE): characteristics of an incident cohort of patients with idiopathic pulmonary fibrosis.BMJ open respiratory research · 2026Observational
- Healthcare professionals' perspectives on implementation of home monitoring in individuals with pulmonary fibrosis.ERJ open research · 2026Article
- Participant Experience, Acceptability and Feasibility of Virtual and Digitally Supported Visits in a Phase IIa COPD Trial.Journal of patient experience · 2026Article
- Remote monitoring of spirometry and oximetry in patients with connective tissue disease related interstitial lung disease: a prospective observational cohort study.BMC pulmonary medicine · 2025Observational
- Pathophysiological Insights and Clinical Management Strategies for Interstitial Lung Diseases.Biomolecules & therapeutics · 2025Review
- Online home spirometry in national pulmonary fibrosis care: insights from daily practice.ERJ open research · 2025Article
- Home is where spirometry should be: enhancing care for individuals with pulmonary fibrosis.ERJ open research · 2025Article
- Home Monitoring in Interstitial Lung Disease: Protocol for a Real-World Observational Study.JMIR research protocols · 2025Article
- Remote Patient Monitoring for Managing Interstitial Lung Disease: A Mixed-Methods Process Evaluation.CHEST pulmonary · 2025Article
- Article
- Assessment of Home-based Monitoring in Adults with Chronic Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- The role of digital health in respiratory diseases management: a narrative review of recent literature.Frontiers in medicine · 2025Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleRecent clinical trial successes have created an urgent need for earlier and more sensitive endpoints of disease progression in idiopathic pulmonary fibrosis (IPF). Domiciliary spirometry permits more frequent measurement of FVC than does hospital-based assessment, which therefore affords the opportunity for a more granular insight into changes in IPF progression.
objectivesTo determine the feasibility and reliability of measuring daily FVC in individuals with IPF.
methodsSubjects with IPF were given handheld spirometers and instruction on how to self-administer spirometry. Subjects recorded daily FEV MEASUREMENTS AND MAIN
resultsDaily spirometry was recorded by 50 subjects for a median period of 279 days (range, 13-490 d). There were 18 deaths during the active study period. Home spirometry showed excellent correlation with hospital-obtained readings. The rate of decline in FVC was highly predictive of outcome and subsequent mortality when measured at 3 months (hazard ratio [HR], 1.040; 95% confidence interval [CI], 1.021-1.062; P ≤ 0.001), 6 months (HR, 1.024; 95% CI, 1.014-1.033; P < 0.001), and 12 months (HR, 1.012; 95% CI, 1.007-1.016; P = 0.001).
conclusionsMeasurement of daily home spirometry in patients with IPF is highly clinically informative and is feasible to perform for most of these patients. The relationship between mortality and rate of change of FVC at 3 months suggests that daily FVC may be of value as a primary endpoint in short proof-of-concept IPF studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.