Evidence map›Paper›PMID 27089012›Full record

ArticleThe journal of physical chemistry. B2016

Translocation of an Incompressible Vesicle through a Pore.

Hamid R Shojaei, Murugappan Muthukumar

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hamid R ShojaeiDepartment of Physics, University of Massachusetts , Amherst, Massachusetts 01003, United States.
Murugappan MuthukumarDepartment of Polymer Science and Engineering, University of Massachusetts , Amherst, Massachusetts 01003, United States.

Funding

Modeling Macromolecular Transport through Protein Channels and NanoporesR01HG002776 · NHGRI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MUTHUKUMAR, MURUGAPPAN · 2003 to 2022
$5.3M
NHGRI NIH HHS R01 HG002776
6 · The paper itself

Abstract

We have derived the free energy landscape for the translocation of a single vesicle through a narrow pore by accounting for bending and stretching of the vesicle, and the deformation of the vesicle by the pore. Emergence of a free energy barrier for translocation is a general result, and the magnitude of the barrier is calculated in terms of the various material parameters. The extent of the reduction in the barrier by the presence of an external constant force is calculated. Using the Fokker-Planck formalism, we have calculated the average translocation time corresponding to the various free energy landscapes representing different parameter sets. The dependencies of the average translocation time on the strength of the external force, vesicle size, bending and stretching moduli of the vesicle, and radius and length of the pore are derived, and the computed results are discussed.

Indexed as

Models, TheoreticalElastic ModulusKineticsMembranes, ArtificialMembranes, Artificial

Identifiers

PMID27089012
PMCPMC4999247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.