ArticleThe Journal of clinical investigation2016
Improved renal ischemia tolerance in females influences kidney transplantation outcomes.
Article in The Journal of clinical investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03663543 (The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation
Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Influence of donor sex and age on graft outcome in kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Pooled it
- Development of a risk prediction score and equation for chronic kidney disease: a retrospective cohort study.Scientific reports · 2023Trial
- Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.Journal of the American Heart Association · 2018Trial
- Clinical outcomes of deceased donor kidney transplantation: Eight years of experience from a tertiary care center in India.World journal of nephrology · 2026Article
- From protection to predisposition: A narrative review of sex-specific vascular responses to acute stressors across the lifespan.Physiological reports · 2026Review
- Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation.Immunological reviews · 2026Review
- Age and sex differences in diabetic ketoacidosis outcomes in type 1 diabetes: a national cohort study.BMJ open diabetes research & care · 2026Article
- Toward an understanding of the intrinsic kidney response to acute injury.Nature reviews. Nephrology · 2026Article
- Kidney Health and Gender-Affirming Hormone Therapy for Transgender and Gender Diverse Individuals.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Life in the fast lane: Functional consequences of male-female dynamic differences in the renal auto-regulation of flow.bioRxiv : the preprint server for biology · 2025Article
- Impact of Donor and Recipient Sex on Long-Term Outcomes Following Living Donor Kidney Transplantation: A Retrospective Dual-Center Study.Clinical transplantation · 2025Observational
- Low-intensity pulsed ultrasound stimulation to treat renal fibrosis through inhibiting tubular IL-1R.JCI insight · 2025Article
- [The importance of sex/gender for graft and patient survival].Innere Medizin (Heidelberg, Germany) · 2025Review
- Mouse orthotopic liver transplantation: Challenges, achievements, and applications.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Review
- Mosaic Loss of Y Chromosome Defines a Proximal Tubular Cell State Associated with Recovery from DGF and of Allograft Quality and Functional Reserve Post DCD Kidney Transplantation.Annals of surgery · 2025Article
- Postkidney Transplant Delayed Graft Function Outcomes Are Not Worsened by Deceased Donor Type.Clinical transplantation · 2025Article
- Association Between Perioperative Hypotension and Graft Function in Kidney Transplantation.Kidney international reports · 2025Article
- Sex and Gender Disparities in Kidney Transplantation.Advances in kidney disease and health · 2025Review
- Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury.Clinical science (London, England : 1979) · 2025Article
- Quinolinic acid potentially links kidney injury to brain toxicity.JCI insight · 2025Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Experimentally, females show an improved ability to recover from ischemia-reperfusion injury (IRI) compared with males; however, this sex-dependent response is less established in humans. Here, we developed a series of murine renal ischemia and transplant models to investigate sex-specific effects on recovery after IRI. We found that IRI tolerance is profoundly increased in female mice compared with that observed in male mice and discovered an intermediate phenotype after neutering of either sex. Transplantation of adult kidneys from either sex into a recipient of the opposite sex followed by ischemia at a remote time resulted in ischemia recovery that reflected the sex of the recipient, not the donor, revealing that the host sex determines recovery. Likewise, renal IRI was exacerbated in female estrogen receptor α-KO mice, while female mice receiving supplemental estrogen before ischemia were protected. We examined data from the United Network for Organ Sharing (UNOS) to determine whether there is an association between sex and delayed graft function (DGF) in patients who received deceased donor renal transplants. A multivariable logistic regression analysis determined that there was a greater association with DGF in male recipients than in female recipients. Together, our results demonstrate that sex affects renal IRI tolerance in mice and humans and indicate that estrogen administration has potential as a therapeutic intervention to clinically improve ischemia tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.