Evidence map›Paper›PMID 27088703›Full record

ArticleEmerging infectious diseases2016

Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.

Bécaye Fall, Marylin Madamet, Cheikhou Camara, Rémy Amalvict, Mansour Fall, Aminata Nakoulima, Bakary Diatta, Yaya Diémé, Boubacar Wade, Bruno Pradines

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cytotoxic and Anti-Plasmodial Activities ofMolecules (Basel, Switzerland) · 2020
    Article
  5. Article
  6. BaselineAntimicrobial agents and chemotherapy · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. SustainedAntimicrobial agents and chemotherapy · 2017
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bécaye Fall
Marylin Madamet
Cheikhou Camara
Rémy Amalvict
Mansour Fall
Aminata Nakoulima
Bakary Diatta
Yaya Diémé
Boubacar Wade
Bruno Pradines

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We successfully cultured 36 Plasmodium falciparum isolates from blood samples of 44 malaria patients admitted to the Hôpital Principal de Dakar (Dakar, Senegal) during August-December 2014. The prevalence of isolates with in vitro reduced susceptibility was 30.6% for monodesethylamodiaquine, 52.8% for chloroquine, 44.1% for mefloquine, 16.7% for doxycycline, 11.8% for piperaquine, 8.3% for artesunate, 5.9% for pyronaridine, 2.8% for quinine and dihydroartemisinin, and 0.0% for lumefantrine. The prevalence of isolates with reduced in vitro susceptibility to the artemisinin-based combination therapy partner monodesethylamodiaquine increased from 5.6% in 2013 to 30.6% in 2014. Because of the increased prevalence of P. falciparum parasites with impaired in vitro susceptibility to monodesethylamodiaquine, the implementation of in vitro and in vivo surveillance of all artemisinin-based combination therapy partners is warranted.

Indexed as

Drug ResistanceAmodiaquineAntimalarialsFemaleHumansInhibitory Concentration 50Malaria, FalciparumMaleParasitic Sensitivity TestsPlasmodium falciparumPrevalenceSenegalAmodiaquineAntimalarialsdesethylamodiaquineantimalarial drugantimicrobial resistanceDakarin vitromalariaparasitesPlasmodium falciparumresistanceSenegalvector-borne infections

Identifiers

PMID27088703
PMCPMC4861513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.