ArticleNature2016
The Atlantic salmon genome provides insights into rediploidization.
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 538 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
538 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,147 citations in OpenAlex.
- Transcriptomic landscape of Atlantic salmon (Salmo salar L.) skin.G3 (Bethesda, Md.) · 2023Pooled it
- Orthology-Aware Reanalysis of Replicated Public Transcriptomes Identifies Shared and Context-Dependent Low-Temperature Responses in Teleost Fishes.Marine biotechnology (New York, N.Y.) · 2026Article
- Developmental contexts of gene-regulatory evolution following whole genome duplication in salmonids.Nature ecology & evolution · 2026Article
- Development constrains the evolution of gene regulation after whole-genome duplication.Nature ecology & evolution · 2026Article
- Fine-tuning neuron number:bioRxiv : the preprint server for biology · 2026Article
- Exploring the Effect of Whole-Genome Duplication on Salmonid LincRNA Repertoire.International journal of molecular sciences · 2026Article
- Catfish Transgenesis and Gene Editing: Overview, Recent Advances, and Future Perspectives.Biology · 2026Review
- A comprehensive and accessible database of jawed-vertebrate ohnologs.Science advances · 2026Article
- Bony fish genomes: Status and gaps.Journal of fish biology · 2026Review
- Article
- Proteomic Profiling Reveals Region-Specific Brain Responses During Acclimation to Elevated Water Temperature in Atlantic Salmon (Proteomes · 2026Article
- Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication.iScience · 2026Article
- Two Decades of DNA Methylation Shifts Reveal Epigenomic Responses to Environmental Change in Wild Salmo salar From Its Southernmost Populations.Molecular ecology · 2026Article
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- Genomes From 117 Vertebrate Species Reveal Rapidly Evolving Segmental-Duplication Landscapes.Genome biology and evolution · 2026Article
- Article
- Effects of Different SNP Calling and Sequence Mapping Choices on the Inference of Genetic Architecture Underlying Migration Tendency.Ecology and evolution · 2026Article
- A chromosome-level genome for gila trout (Oncorhynchus gilae) provides a novel resource for conservation and management.BMC genomics · 2026Article
- Haplotype-resolved genome ofZoological research · 2026Article
- Schizothoracinae in Plateau River Networks: Drainage History, Polyploid Genome Evolution, Multi-Omics Evidence Chains, and Conservation Units.Animals : an open access journal from MDPI · 2026Review
478 more citing papers are in PubMed but not listed here.
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Authors and funding
45 authors at 16 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.