ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Pooled it
- Article
- Metabolomic Profiling of Osteoblasts in Rat Subchondral Bone Following Anterior Cruciate Ligament Injury.Molecules (Basel, Switzerland) · 2025Article
- Gait Asymmetry and Post-Traumatic Osteoarthritis Following Anterior Cruciate Ligament Rupture: A Preliminary Study.Biology · 2025Article
- Article
- The intersection of aging and estrogen in osteoarthritis.npj women's health · 2025Review
- Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models.Disease models & mechanisms · 2024Article
- Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.Scientific reports · 2024Article
- PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice.Science advances · 2024Article
- Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain.Arthritis research & therapy · 2024Article
- MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathwayHeliyon · 2024Article
- Article
- A Systemic and Local Comparison of Senescence in an Acute Anterior Cruciate Ligament Injury-A Pilot Case Series.Life (Basel, Switzerland) · 2023Article
- Full and Partial Mid-substance ACL Rupture Using Mechanical Tibial Displacement in Male and Female Mice.Annals of biomedical engineering · 2023Article
- Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament.PloS one · 2023Article
- Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models.Stem cell research & therapy · 2022Article
- Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis.JBMR plus · 2022Article
- Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data.JBMR plus · 2022Review
- Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Joint injury causes post-traumatic osteoarthritis (PTOA). About ∼50% of patients rupturing their anterior cruciate ligament (ACL) will develop PTOA within 1-2 decades of the injury, yet the mechanisms responsible for the development of PTOA after joint injury are not well understood. In this study, we examined whole joint gene expression by RNA sequencing (RNAseq) at 1 day, 1-, 6-, and 12 weeks post injury, in a non-invasive tibial compression (TC) overload mouse model of PTOA that mimics ACL rupture in humans. We identified 1446 genes differentially regulated between injured and contralateral joints. This includes known regulators of osteoarthritis such as MMP3, FN1, and COMP, and several new genes including Suco, Sorcs2, and Medag. We also identified 18 long noncoding RNAs that are differentially expressed in the injured joints. By comparing our data to gene expression data generated using the surgical destabilization of the medial meniscus (DMM) PTOA model, we identified several common genes and shared mechanisms. Our study highlights several differences between these two models and suggests that the TC model may be a more rapidly progressing model of PTOA. This study provides the first account of gene expression changes associated with PTOA development and progression in a TC model. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 35:474-485, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.