Evidence map›Paper›PMID 27088118›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2016

Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity.

Marilyn McKasson, Stacey L Clardy, Susan A Clawson, Kenneth E Hill, Blair Wood, Noel Carlson, Mark Bromberg, John E Greenlee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.Neurology(R) neuroimmunology & neuroinflammation · 2022
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. A box of chocolates.Neurology(R) neuroimmunology & neuroinflammation · 2016
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marilyn McKassonDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Stacey L ClardyDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Susan A ClawsonDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Kenneth E HillDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Blair WoodDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Noel CarlsonDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
Mark BrombergDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
John E GreenleeDepartments of Neurology (M.M., S.L.C., N.C., M.B., J.E.G.) and Neurobiology and Anatomy (N.C.), University of Utah, Salt Lake City; and Department of Veterans Affairs Medical Center (S.L.C., S.A.C., K.E.H., B.W., N.C., J.E.G.), Salt Lake City, UT.
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe response to treatment in a patient with autoantibodies against voltage-gated calcium channels (VGCCs) who presented with autoimmune cerebellar degeneration and subsequently developed Lambert-Eaton myasthenic syndrome (LEMS), and to study the effect of the patient's autoantibodies on Purkinje cells in rat cerebellar slice cultures.

methodsCase report and study of rat cerebellar slice cultures incubated with patient VGCC autoantibodies.

resultsA 53-year-old man developed progressive incoordination with ataxic speech. Laboratory evaluation revealed VGCC autoantibodies without other antineuronal autoantibodies. Whole-body PET scans 6 and 12 months after presentation detected no malignancy. The patient improved significantly with IV immunoglobulin G (IgG), prednisone, and mycophenolate mofetil, but worsened after IV IgG was halted secondary to aseptic meningitis. He subsequently developed weakness with electrodiagnostic evidence of LEMS. The patient's IgG bound to Purkinje cells in rat cerebellar slice cultures, followed by neuronal death. Reactivity of the patient's autoantibodies with VGCCs was confirmed by blocking studies with defined VGCC antibodies.

conclusionsAutoimmune cerebellar degeneration associated with VGCC autoantibodies may precede onset of LEMS and may improve with immunosuppressive treatment. Binding of anti-VGCC antibodies to Purkinje cells in cerebellar slice cultures may be followed by cell death. Patients with anti-VGCC autoantibodies may be at risk of irreversible neurologic injury over time, and treatment should be initiated early.

Identifiers

PMID27088118
PMCPMC4821674
OpenAlexW2318755620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.