Evidence map›Paper›PMID 27088023›Full record

ArticleCase reports in otolaryngology2016

Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer.

Alhasan Elghouche, Tom Shokri, Yewen Qin, Susannah Wargo, Deborah Citrin, Carter Van Waes

Open access · goldAbstract read
In one paragraph

Article in Case reports in otolaryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Induction and Regulation of the Immunoproteasome Subunit β5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  4. A rare case of chemotherapy induced phrenic neuropathy.Respiratory medicine case reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Alhasan ElghoucheIndiana University School of Medicine, 1120 W. Michigan Street, Suite 200, Indianapolis, IN 46202, USA.
Tom ShokriDivision of Otolaryngology, Penn State Milton S. Hershey Medical Center, 100 Campus Drive, Suite 400, Hershey, PA 17033, USA.
Yewen QinKing's College London School of Medicine, Strand, London WC2R 2LS, UK.
Susannah WargoHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Deborah CitrinRadiation Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Carter Van WaesHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, 9000 Rockville Pike, Bethesda, MD 20892, USA.
National Institute on Deafness and Other Communication Disorders · USCenter for Cancer Research · USIndiana University School of MedicineKing's College London · GBPenn State Milton S. Hershey Medical Center · US

Funding

NIDCD Core for Clinical Research and CareZIDDC000075 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI LEVY, JOSHUA · 2009 to 2025
$33.6M
Signal and Transcription Factor Network interactions in Head and Neck CancerZIADC000073 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI VAN WAES, CARTER · 2009 to 2022
$9.1M
PHYSIOLOGY AND ACOUSTICS OF SPEECHR01DC000075 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI STEVENS, KENNETH N · 1989 to 2007
$3.2M
NIDCD Core for Clinical Research and CareZ01DC000075 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI VAN WAES, CARTER · 2008 to 2008
$1.1M
Intramural NIH HHS Z01 DC000075NIDCD NIH HHS R01 DC000075
6 · The paper itself

Abstract

We report a constellation of cervical polyneuropathies in a patient treated with concurrent bortezomib, cetuximab, and cisplatin alongside intensity modulated radiotherapy for carcinoma of the tonsil with neck metastasis. The described deficits include brachial plexopathy, cervical sensory neuropathy, and oculosympathetic, recurrent laryngeal, and phrenic nerve palsies within the ipsilateral radiation field. Radiation neuropathy involving the brachial plexus is typically associated with treatment of breast or lung cancer; however, increased awareness of this entity in the context of investigational agents with potential neuropathic effects in head and neck cancer has recently emerged. With this report, we highlight radiation neuropathy in the setting of investigational therapy for head and neck cancer, particularly since these sequelae may present years after therapy and entail significant and often irreversible morbidity.

Identifiers

PMID27088023
PMCPMC4818816
OpenAlexW2279548558

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.