ArticleUnited European gastroenterology journal2016
Nickel sensitization in patients with gastro-esophageal reflux disease.
Article in United European gastroenterology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Systemic Nickel Allergy Syndrome.American journal of medicine open · 2026Review
- A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022Review
- The effect of a low-nickel diet and nickel sensitization on gastroesophageal reflux disease: A pilot study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Editorial commentary on the Indian Journal of Gastroenterology - March-April 2021.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders.Clinical reviews in allergy & immunology · 2019Review
- Nickel allergy in lipid transfer protein sensitized patients: Prevalence and clinical features.International journal of immunopathology and pharmacologyObservational
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastro-esophageal reflux disease (GERD) leads to frequent medical visits, and available therapies fail in up to 40% of patients. Food allergies may be involved in GERD pathogenesis; however, allergens other than food have received little attention. Nickel allergy is common in the general population and some high-nickel foods are associated with GERD. However, the potential relationship between nickel allergy and GERD remains unaddressed.
aimThis study aimed to evaluate the prevalence of nickel sensitization in patients with and without GERD and to compare clinical and demographic features.
methodsThis prospective, multicenter study included 210 adult GERD patients and 140 patients without GERD who presented at the general practitioner. All GERD patients had undergone treatment with proton pump inhibitors and upper digestive endoscopy within the previous five years. Demographic and clinical data were collected by questionnaire and patients underwent a nickel patch allergy test.
resultsPatients with and without GERD presented similar characteristics, with the exception of nickel sensitization, which was significantly more prevalent among GERD patients than controls (39.5% vs. 16.4%; p = 0.001). Nickel-positive GERD patients were more frequently female (90.4% vs. 65.4%, p = 0.003) and asthmatic (18.1% vs. 4.7%; p = 0.038), compared to nickel-negative GERD patients. At six-month follow-up, most of the patients, with or without nickel sensitization, reported improved symptoms without differences in drug prescription.
conclusionNickel sensitization is particularly prevalent in GERD patients seen in general practice. Whether allergies other than food allergy play a role in GERD remains to be elucidated.
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