Evidence map›Paper›PMID 27087910›Full record

ArticleComputational and structural biotechnology journal2016

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Anthony C Dona, Michael Kyriakides, Flora Scott, Elizabeth A Shephard, Dorsa Varshavi, Kirill Veselkov, Jeremy R Everett

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Metabolites · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Phenotypic and metabonomics studies of FMOs in C. elegans and their roles in lifespan extension.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  13. The influence ofMicrobiology (Reading, England) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anthony C DonaDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.
Michael KyriakidesDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.
Flora ScottInstitute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
Elizabeth A ShephardInstitute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
Dorsa VarshaviMedway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, United Kingdom.
Kirill VeselkovDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.
Jeremy R EverettMedway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in biological fluids: nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), the latter typically with hyphenation to a chromatography system such as liquid chromatography (LC), in a configuration known as LC-MS. With both NMR and MS-based detection technologies, the identification of the metabolites in the biological sample remains a significant obstacle and bottleneck. This article provides guidance on methods for metabolite identification in biological fluids using NMR spectroscopy, and is illustrated with examples from recent studies on mice.

Indexed as

Metabolite identificationMetabolomicsMetabonomicsMolecular structureNuclear magnetic resonance (NMR) spectroscopy

Identifiers

PMID27087910
PMCPMC4821453

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.