ArticleScientific reports2016
Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Novel netrin-1-Unc5b-Klf4 axis balances AT2 survival in experimental bronchopulmonary dysplasia.American journal of respiratory cell and molecular biology · 2026Article
- Heavy moms, wheezy kids: how maternal obesity harms breathing in offspring.American journal of respiratory cell and molecular biology · 2026Review
- Increased allergic inflammation and decreased lung insulin sensitivity in offspring of obese allergic mothers.Journal of leukocyte biology · 2024Article
- CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia.Inflammation and regeneration · 2023Article
- Identification and analysis of lipid metabolism-related genes in allergic rhinitis.Lipids in health and disease · 2023Article
- Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.Metabolites · 2023Article
- Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling.International journal of molecular sciences · 2023Article
- Increased serum cotinine and obesity negatively impact asthma exacerbations and hospitalizations: A cross-sectional analysis of NHANES.Journal of clinical and translational science · 2023Article
- Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.Nature communications · 2022Article
- Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice.International journal of molecular sciences · 2022Article
- Airway immune response in the mouse models of obesity-related asthma.Frontiers in physiology · 2022Review
- Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases.Frontiers in medicine · 2021Review
- Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams.Clinical and translational science · 2020Article
- Potential Role of Cellular Senescence in Asthma.Frontiers in cell and developmental biology · 2020Review
- Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring.Nutrients · 2019Article
- Epigenetic underpinnings of developmental immunotoxicity and autoimmune disease.Current opinion in toxicology · 2018Article
- Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Obesogenic diets alter metabolism in mice.PloS one · 2018Article
- Maternal high-fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring.Physiological reports · 2017Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since obesity leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation leads to early-onset obesity and dysregulates pulmonary adipocytokine/insulin signaling, resulting in metabolic programming of asthma-like disease in adult mice. Offspring with pHA showed at postnatal day 21 (P21): (1) early-onset obesity, greater fat-mass, increased expression of IL-1β, IL-23, and Tnf-α, greater serum leptin and reduced glucose tolerance than Control (Ctrl); (2) less STAT3/AMPKα-activation, greater SOCS3 expression and reduced AKT/GSK3β-activation in the lung, indicative of leptin resistance and insulin signaling, respectively; (3) increased lung mRNA of IL-6, IL-13, IL-17A and Tnf-α. At P70 body weight, fat-mass, and cytokine mRNA expression were similar in the pHA and Ctrl, but serum leptin and IL-6 were greater, and insulin signaling and glucose tolerance impaired. Peribronchial elastic fiber content, bronchial smooth muscle layer, and deposition of connective tissue were not different after pHA. Despite unaltered bronchial structure mice after pHA exhibited significantly increased airway reactivity. Our study does not only demonstrate that early-onset obesity transiently activates pulmonary adipocytokine/insulin signaling and induces airway hyperreactivity in mice, but also provides new insights into metabolic programming of childhood obesity-related asthma.
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