Evidence map›Paper›PMID 27087682›Full record

SynthesisScientific reports2016

Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis.

Dan Xing, Yuankun Xu, Qiang Liu, Yan Ke, Bin Wang, Zhichang Li, Jianhao Lin

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan XingArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Yuankun XuArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Qiang LiuArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Yan KeArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Bin WangArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Zhichang LiArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.
Jianhao LinArthritis Clinic &Research Center, Peking University People's Hospital, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study is to investigate the association between osteoarthritis (OA) and all-cause mortality in worldwide populations and to develop recommendations according to GRADE evidence levels. Literature search through Nov 2015 was performed using the electronic databases (including MEDLINE, EMBASE, EBSCO and Cochrane library). The prospective cohort trials that investigated the association between the symptomatic OA (SxOA) or radiological OA (ROA) and all-cause mortality were identified. Hazard ratios (HR) of all-cause mortality in patients with RxOA or ROA were pooled respectively. The evidence quality was evaluated using the GRADE system, while the recommendations were taken according to the quality. Nine of the published literature met the eligible criteria. Meta-analysis revealed that there was no significant difference in the association between SxOA and all-cause mortality (HR = 0.91, 95% CI: 0.68-1.23) and between ROA and all-cause mortality (HR = 1.13, 95% CI: 0.95-1.35). The overall GARDE evidence quality was very low, which will lower our confidence in taking recommendations. To summarize, there was no reliable and confident evidence existed currently in respect of the association between OA and all-cause mortality. Due to the very low level of evidence quality currently, high-quality studies are still required.

Indexed as

Cohort StudiesHumansMortalityOsteoarthritisProspective StudiesRisk

Identifiers

PMID27087682
PMCPMC4834546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.