ArticleNeuromolecular medicine2016
Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of iNOS, COX-2 Expression and NFκ-B Signaling Pathway.
Article in Neuromolecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.Current neuropharmacology · 2021Pooled it
- Plant Essential Oils and Chronic Inflammatory Diseases: A Panoramic View of Molecular Mechanisms.Drug design, development and therapy · 2026Review
- The effect of cinnamon bark oil in bilateral common carotid artery occlusion-induced cerebral ıischemia model in rats.Scientific reports · 2025Article
- Article
- The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders.Antioxidants (Basel, Switzerland) · 2024Review
- Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury.World neurosurgery: X · 2024Article
- Exploring the Therapeutic Potential of Phytoconstituents for Addressing Neurodegenerative Disorders.Central nervous system agents in medicinal chemistry · 2024Review
- Article
- Article
- Cinnamon: an aromatic condiment applicable to chronic kidney disease.Kidney research and clinical practice · 2023Article
- Contribution of Aldehydes and Their Derivatives to Antimicrobial and Immunomodulatory Activities.Molecules (Basel, Switzerland) · 2022Review
- Cinnamaldehyde Increases the Survival of Mice Submitted to Sepsis Induced by Extraintestinal PathogenicAntibiotics (Basel, Switzerland) · 2022Article
- Review
- Polysaccharide derived fromAmerican journal of translational research · 2022Article
- Inhalation AromatherapyFrontiers in pharmacology · 2022Review
- Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System.Plants (Basel, Switzerland) · 2021Review
- Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model.BMC pharmacology & toxicology · 2021Article
- Targeting Common Signaling Pathways for the Treatment of Stroke and Alzheimer's: a Comprehensive Review.Neurotoxicity research · 2021Review
- The Extracts ofOxidative medicine and cellular longevity · 2021Article
- Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses byInternational journal of medical sciences · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trans-cinnamaldehyde (TCA), an essential oil in cinnamon powder, may have beneficial effects as a treatment for stroke which is the second leading cause of death worldwide. Post-ischemic inflammation induces neuronal cell damage after stroke, and activation of microglia, in particular, has been thought as the main contributor of proinflammatory and neurotoxic factors. The purpose of this study was to investigate the neuroprotective effects of TCA in an animal model of ischemia/reperfusion (I/R)-induced brain injury and the neuroprotective mechanism was verified in LPS-induced inflammation of BV-2 microglial cells. Our results showed that TCA (10-30 mg/kg, p.o.) significantly reduced the infarction area, neurological deficit score and decreased iNOS and COX-2 protein expression level in I/R-induced injury brain tissue. It inhibited 0.5 µg/ml LPS-induced NO production in BV-2 microglial cells without affecting cell viability, reduced protein expression of iNOS and COX-2, and attenuated inhibition of p53 protein. TCA also suppressed the effects of LPS-induced nuclear translocation of NF-κB p65 and p50 and increased cytosolic IκBα. It also reduced LPS-induced mRNA expression of iNOS, COX-2, and TNFα. We concluded that TCA has a potential neuroprotective effect to against the ischemic stroke, which may be via the inhibition of neuroinflammation through attenuating iNOS, COX-2 expression and NF-κB signaling pathway.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.