Evidence map›Paper›PMID 27087578›Full record

SynthesisInternational journal of cancer2016

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.

Jiajun Shi, Yanfeng Zhang, Wei Zheng, Kyriaki Michailidou, Maya Ghoussaini, Manjeet K Bolla, Qin Wang, Joe Dennis, Michael Lush, Roger L Milne and 119 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  8. Frontiers in oncology · 2022
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors at 20 institutions in 24 countries.

Jiajun Shi *Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Yanfeng Zhang *Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Maya GhoussainiCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Michael LushCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Roger L MilneCancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Jonathan BeesleyDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Siddhartha KarCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, CA 92697, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany.
Matthias W BeckmannDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany.
Zhiguo ZhaoDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Xingyi GuoDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Javier BenitezHuman Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid 28029, Spain.
Alicia Beeghly-FadielDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, Hannover 30625, Germany.
Stig E BojesenCopenhagen General Population Study, Herlev Hospital, 2730 Herlev, Denmark.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg 69120, Germany.
Louise BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Annegien BroeksNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands.
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum 44789, Germany.
Barbara BurwinkelDivision of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany.
Hui CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Sander CanisiusNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, the Netherlands.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Angela CoxSheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Peter DevileeSepartment of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Arnaud DroitCentre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada.
Thilo DorkGynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany.
Peter A FaschingDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany.
Olivia FletcherDivision of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.
Henrik FlygerDepartment of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Florentia FostiraMolecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", 153 10 Athens, Greece.
Valerie GaborieauInternational Agency for Research on Cancer, Lyon 69372, France.
Montserrat García-ClosasDivision of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.
Graham G GilesCancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
Mervi Grip
Pascal GuenelEnvironmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore.
Hui MiaoSaw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore.
Antoinette HollestelleDepartment of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands.
John L HopperDivision of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany.
Chia-Ni HsiungInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
kConFab Investigators
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi 464-8681, Japan.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Nichola JohnsonDivision of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Maria KabischMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Daehee KangDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea.
Sofia KhanDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Veli-Matti KosmaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan.
Diether LambrechtsVesalius Research Center, Leuven 3000, Belgium.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden.
Artitaya LophatananonDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland.
Arto MannermaaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finlan.
Siranoush ManoukianUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan 20133, Italy.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Sara MargolinDepartment of Oncology - Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden.
Frederik MarmeNational Center for Tumor Diseases, University of Heidelberg, Heidelberg 69120, Germany.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Melbourne, , Victoria 3004, Australia.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, Munich 81675, Germany.
Kenneth MuirDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Susan L NeuhausenBeckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland.
Silje NordDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway.
Anne-Lise Børresen-DaleDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Nick OrrDivision of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London SW3 6JB, UK.
Ans M W van den OuwelandDepartment of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Paolo PeterlongoIFOM, the FIRC Institute of Molecular Oncology, Milan 20139, Italy.
Thomas Choudary PuttiDepartment of Pathology, National University Health System, Singapore 117597.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany.
Suleeporn SangrajrangNational Cancer Institute, Bangkok 10400, Thailand.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London SE1 9RT, UK.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam 1066 CX, The Netherlands.
Rita K SchmutzlerDivision of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne 50931, Germany.
Chen-Yang ShenSchool of Public Health, China Medical University, Taichung 404, Taiwan.
Ming-Feng HouCancer Center and Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Matha J ShrubsoleDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Anthony SwerdlowDivision of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London SW7 3RP, UK.
Soo Hwang TeoCancer Research Initiatives Foundation, 47500 Subang Jaya, Selangor, Malaysia.
Bernard ThienpontVesalius Research Center, Leuven 3000, Belgium.
Amanda E TolandDepartment of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Robert A E M TollenaarDepartment of Surgical Oncology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Therese TruongEnvironmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 94807, France.
Chiu-Chen TsengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu FI-90220, Finland.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Cheng Har YipBreast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, 59100 KualaLumpur, Malaysia.
Pilar M ZamoraServicio de Oncología Médica, Hospital Universitario La Paz, Madrid 28046, Spain.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, PR China.
Giuseppe FlorisUniversity Hospital Gashuisberg, Leuven, Belgium.
Ching-Yu ChengSingapore Eye Research Institute, National University of Singapore, Singapore, Singapore.
Maartje J HooningDepartment of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands.
John W M MartensDepartment of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands.
Caroline SeynaeveDepartment of Medical Oncology, Erasmus MC Cancer Institute, 3015 CN Rotterdam, The Netherlands.
Vessela N KristensenDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Jacques SimardCentre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City G1V 4G2, Canada.
Georgia Chenevix-TrenchDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Vanderbilt University · USGerman Cancer Research Center · DEUniversity of Cambridge · GBInstitute of Cancer Research · GBKarolinska Institutet · SEOslo University Hospital · NOThe University of Melbourne · AUUniversity of Eastern Finland · FIUniversity of Southern California · USErasmus MC Cancer Institute · NLNational University of Singapore · SGUniversité Paris-Sud · FRUniversity Malaya Medical Centre · MYAichi Cancer Center · JPChina Medical University · TWGuy's Hospital · GBKyushu University · JPLeiden University Medical Center · NLMedizinische Hochschule Hannover · DEMount Sinai Hospital · CA

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 16565Medical Research Council MC_PC_14105NCI NIH HHS N01 CN025403NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA122340NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA148667NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA182910Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2)  = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.

Indexed as

Chromosome MappingGenetic VariationQuantitative Trait LociAllelesBreast NeoplasmsCase-Control StudiesChromosomes, Human, Pair 8FemaleGenome-Wide Association StudyGenotypeHaplotypesHumansLinkage DisequilibriumOdds RatioPolymorphism, Single NucleotideRisk8q24breast cancerfine-mappinggenetic susceptibilitysingle nucleotide polymorphism

Identifiers

PMID27087578
PMCPMC5110427
OpenAlexW2418306222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.