ArticleScientific reports2016
Hemoglobin consumption by P. falciparum in individual erythrocytes imaged via quantitative phase spectroscopy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Precise gene regulation through transcriptional repression is essential for Plasmodium berghei asexual blood stage development.Nature communications · 2026Article
- Oxidative stress in malaria and typhoid fever: A scoping review of the pathogenic mechanisms and therapeutic implications.PLOS global public health · 2025Article
- Two-dimensional Graphene/MoS2 vertical heterostructure for detection of hemoglobin concentration in blood samples.PloS one · 2024Article
- Quantitative Measurements of Red Blood Cell Indices Using Spectroscopic Differential Phase-Contrast Microscopy.Chemical & biomedical imaging · 2023Article
- Refractive Index of Hemoglobin Analysis: A Comparison of Alternating Conditional Expectations and Computational Intelligence Models.ACS omega · 2022Article
- Label-free hematology analysis method based on defocusing phase-contrast imaging under illumination of 415 nm light.Biomedical optics express · 2022Article
- Review
- Plasmepsin-like Aspartyl Proteases inPathogens (Basel, Switzerland) · 2021Article
- Single Cell Analysis of Stored Red Blood Cells Using Ultra-High Throughput Holographic Cytometry.Cells · 2021Article
- Multiparametric biophysical profiling of red blood cells in malaria infection.Communications biology · 2021Article
- Acoustofluidic phase microscopy in a tilted segmentation-free configuration.Biomicrofluidics · 2021Article
- Automatic detection and characterization of quantitative phase images of thalassemic red blood cells using a mask region-based convolutional neural network.Journal of biomedical optics · 2020Article
- Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.Biophysical journal · 2019Article
- Quantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes.Microsystems & nanoengineering · 2019Article
- Invited Article: Digital refocusing in quantitative phase imaging for flowing red blood cells.APL photonics · 2018Article
- Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography.Scientific reports · 2017Article
- Refractive index tomograms and dynamic membrane fluctuations of red blood cells from patients with diabetes mellitus.Scientific reports · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Plasmodium falciparum infection causes structural and biochemical changes in red blood cells (RBCs). To quantify these changes, we apply a novel optical technique, quantitative phase spectroscopy (QPS) to characterize individual red blood cells (RBCs) during the intraerythrocytic life cycle of P. falciparum. QPS captures hyperspectral holograms of individual RBCs to measure spectroscopic changes across the visible wavelength range (475-700 nm), providing complex information, i.e. amplitude and phase, about the light field which has interacted with the cell. The complex field provides complimentary information on hemoglobin content and cell mass, which are both found to dramatically change upon infection by P. falciparum. Hb content progressively decreases with parasite life cycle, with an average 72.2% reduction observed for RBCs infected by schizont-stage P. falciparum compared to uninfected cells. Infection also resulted in a 33.1% reduction in RBC's optical volume, a measure of the cells' non-aqueous components. Notably, optical volume is only partially correlated with hemoglobin content, suggesting that changes in other dry mass components such as parasite mass may also be assessed using this technique. The unique ability of QPS to discriminate individual healthy and infected cells using spectroscopic changes indicates that the approach can be used to detect disease.
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