Evidence map›Paper›PMID 27087433›Full record

ArticlePsychopharmacology2016

The adenosinergic system is involved in sensitization to morphine withdrawal signs in rats-neurochemical and molecular basis in dopaminergic system.

Joanna Listos, Irena Baranowska-Bosiacka, Agnieszka Wąsik, Sylwia Talarek, Maciej Tarnowski, Piotr Listos, Małgorzata Łupina, Lucyna Antkiewicz-Michaluk, Izabela Gutowska, Marta Tkacz and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Mechanisms Involved in Morphine Addiction: An Overview.International journal of molecular sciences · 2019
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Joanna ListosDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. a.listos@umlub.pl.
Irena Baranowska-BosiackaDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland.
Agnieszka WąsikDepartment of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12 St., 31-343, Kraków, Poland.
Sylwia TalarekDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland.
Maciej TarnowskiDepartment of Physiology, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland.
Piotr ListosDepartment of Pathological Anatomy, Faculty of Veterinary Medicine, University of Life Sciences, Głęboka 30 St., 20-612, Lublin, Poland.
Małgorzata ŁupinaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland.
Lucyna Antkiewicz-MichalukDepartment of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12 St., 31-343, Kraków, Poland.
Izabela GutowskaDepartment of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24 St., 71-460, Szczecin, Poland.
Marta TkaczDepartment of Physiology, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland.
Anna PilutinDepartment of Histology and Embryology, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland.
Jolanta Orzelska-GórkaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland.
Dariusz ChlubekDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111, Szczecin, Poland.
Sylwia FideckaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland.
Pomeranian Medical University · PLMedical University of Lublin · PLMaj Institute of Pharmacology · PLUniversity of Life Sciences in Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleExperimental data informs that not only do the dose and time duration of dependent drugs affect the severity of withdrawal episodes. Previous withdrawal experiences may intensify this process, which is referred as sensitization to withdrawal signs. Adenosine and dopamine (DA) receptors may be involved in this sensitization.

objectivesRats were continuously and sporadically treated with increasing doses of morphine for 8 days. In rats, sporadically treated with morphine, morphine administration was modified by adding three morphine-free periods. Adenosine agonists were given during each of the morphine-free periods (six injections in total). On the 9th day, morphine was injected. One hour later, naloxone was administered to induce morphine withdrawal signs. Then, the animals were placed into cylinders and the number of jumpings was recorded. Next, the rats were decapitated and brain and brain structures (striatum, hippocampus, and prefrontal cortex) were dissected for neurochemical, molecular, and immunohistochemical experiments within DAergic pathways.

resultsWe demonstrated that previous experiences of opioid withdrawal intensified subsequent withdrawal signs. Adenosine ligands attenuated the sensitization to withdrawal signs. In a neurochemical study, the release of DA and its metabolites was impaired in all structures. Significant alterations were also observed in mRNA and protein expression of DA receptors.

conclusionsResults demonstrate that intermittent treatment with morphine induces alterations in the DAergic system which may be responsible for sensitization to morphine withdrawal signs. Although adenosine ligands attenuate this type of sensitization, they are not able to fully restore the physiological brain status.

Indexed as

AdenosineAnalgesics, OpioidAnimalsBehavior, AnimalDopamineMaleMorphineMorphine DependenceNaloxoneNarcotic AntagonistsRatsRats, WistarReceptors, DopamineRNA, MessengerSubstance Withdrawal SyndromeAdenosineAnalgesics, OpioidDopamineMorphineNaloxoneNarcotic AntagonistsReceptors, DopamineRNA, MessengerDependenceDopamine receptor expressionMorphine withdrawal signsNaloxone

Identifiers

PMID27087433
PMCPMC4873537
OpenAlexW2341368189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.